| Document ID (ISN) | 78835 |
| CIS number |
02-828 |
| ISSN - Serial title |
0007-9952 - Cahiers de notes documentaires - Hygiène et sécurité du travail |
| Year |
2001 |
| Convention or series no. |
INRS ND 2157-185-01
|
| Author(s) |
Iwatsubo Y., Pairon J.C., Boutin C., Menard O., Massin N., Caillaud D., Orlowski E., Galateau-Salle F., Bignon J., Brochard P. |
| Title |
Dose-response relationship between low levels of asbestos and pleural mesothelioma - Population-based case-control study in France |
| Original title |
Relation dose-effet entre faibles niveaux d'exposition à l'amiante et mésothéliome pleural - Etude cas-témoins en population générale française [in French] |
| Bibliographic information |
4th Quarter 2001, No.185, p.7-16. 52 ref. |
| Abstract |
The relationship between prior occupational exposure to asbestos and pleural mesothelioma was studied in 405 cases and 387 controls among hospital patients between 1987 and 1993. Exposure to asbestos fibres was evaluated by a group of experts in terms of the probability, intensity and frequency of exposure. Among men, the odds ratio (OR) increased with probability of exposure from 1.2 for possible exposure to 3.6 for cases where exposure was certain. A dose-effect relationship was observed with the cumulative exposure index: the OR increased from 1.2 for the least-exposed category to 8.7 for the most-exposed category. Among women, the OR was 18.8 for cases where exposure was possible or certain. This study enabled the highlighting of a clear relationship between cumulative exposure to asbestos and pleural mesothelioma. A significant excess of mesothelioma was observed for exposure levels that were probably far below the limits adopted by most industrialized countries during the 1980s. |
| Descriptors (primary) |
asbestos; dose-response relationship; pleural mesothelioma |
| Descriptors (secondary) |
France; exposure evaluation; frequency rates; long-term exposure; sex-linked differences; case-control study |
| Document type |
D - Periodical articles |
| Country / State or Province | France |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Diseases of the respiratory system (except for pneumoconiosis & similar)
Asbestos
|
