| Document ID (ISN) | 78665 |
| CIS number |
02-577 |
| ISBN(s) |
92-4-153039-1 |
| Year |
2002 |
| Convention or series no. |
CICAD No.39
|
| Author(s) |
Inter-Organization Programme for the Sound Management of Chemicals (IOMC) |
| Title |
Acrylonitrile |
| Bibliographic information |
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 2002. iv, 51p. Illus. Approx. 220 ref. |
| Internet access |
http://www.who.int/ipcs/publications/cicad/en/cicad39.pdf [in English]
|
| Abstract |
Conclusions of this criteria document on acrylonitrile: data from animal studies indicate that the product is a skin, respiratory and severe eye irritant. Acute dermal irritation has been reported in human studies. Animal ingestion and inhalation studies have given rise to the consistent observation of cancers (of the brain and spinal cord, ear canal, gastrointestinal tract and mammary glands), including upon the administration of non-toxic doses. Increases in cancer incidence have not been confirmed in epidemiological studies involving exposed workers, in part due to the limited number of published studies. |
| Descriptors (primary) |
IPCS; toxicology; acrylonitrile |
| Descriptors (secondary) |
toxic effects; literature survey; irritants; epidemiological aspects; ILO; criteria document; WHO; cancer; ecotoxicology; animal experiments; UNEP |
| Document type |
B - Chemical safety information sheets |
| Country / State or Province | WHO |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Cyano compounds
|
