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CISDOC database

Document ID (ISN)78617
CIS number 02-571
ISBN(s) 3-7776-1100-X
Year 2001
Convention or series no. BUA Report 222
Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Title Genistein - Model substance for describing endocrine effects of phytoestrogens
Bibliographic information S. Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2001. xviii, 134p. 237 ref.
Abstract Based on a literature survey, this report reviews the effects of genostein. Genostein is a phyto-estrogen, i.e. its effects are similar to those of estrogens. High concentrations of genostein are found notably in soybeans which are a staple food in Asia. It is therefore important to understand the pharmacokinetics, metabolism and induced effects of this product. At genistein concentrations corresponding to those of the typical Asian diet, findings included relatively low effects on the hormonal system and a lengthening of the menstrual cycle among pre-menopausal women. These effects may influence cancer incidence rates, in particular for breast cancer. However, many studies highlight the beneficial effects of diets rich in genostein or phyto-estrogens. In vitro studies and animal experiments show genistein to have toxicological properties similar to those of estrogens.
Descriptors (primary) toxic effects; Germany; endocrine effects; plants; ecotoxicology; oestrogens
Descriptors (secondary) literature survey; soya beans; diet; criteria document; animal experiments; in vitro experiments; menstrual cycle
Document type B - Chemical safety information sheets
Country / State or ProvinceGermany
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Pollution control