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Document ID (ISN)78609
CIS number 02-819
ISSN - Serial title 1077-3525 - International Journal of Occupational and Environmental Health
Year 2001
Convention or series no.
Author(s) Bar-Sela S., Reingold S., Richter E.D.
Title Amyotrophic lateral sclerosis in a battery-factory worker exposed to cadmium
Bibliographic information Apr.-June 2001, Vol.7, No.2, p.109-112. 49 ref.
Abstract A 44-year-old patient died from amyotrophic lateral sclerosis (ALS) after nine years of heavy exposure to cadmium (Cd) in a nickel-cadmium battery plant. Two years after starting work, he and co-workers had experienced pruritus, loss of smell, nasal congestion, nosebleeds, cough, shortness of breath, severe headaches, bone pain, and proteinuria. Upper back pain and muscle weakness progressed to flaccid paralysis. EMG findings were consistent with motor neuron disease. Cd impairs the blood-brain barrier, reduces levels of brain copper-zinc superoxide dismutase and enhances glutamate uptake in glial cells. High levels of methallothionein, a sign of exposure to heavy metals, have been found in brain tissue of deceased ALS patients. The effects of Cd on enzyme systems that mediate neurotoxicity and motor neuron disease suggest a relationship between Cd and ALS in this worker.
Descriptors (primary) amyotrophic lateral sclerosis; cadmium; battery and dry cell manufacture
Descriptors (secondary) neurotoxic effects; case study; enzyme disturbances; long-term exposure; neuromuscular disorders; electromyography; symptoms
Document type D - Periodical articles
Country / State or ProvinceIsrael
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the nervous system
Manufacturing of electrical appliances and equipment
Cadmium and compounds
Inorganic substances