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CISDOC database

Document ID (ISN)78539
CIS number 02-815
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2001
Convention or series no.
Author(s) Luo J.C., Kuo H.W., Cheng T.J., Chang M.J.W.
Title Abnormal liver function associated with occupational exposure to dimethylformamide and hepatitis B virus
Bibliographic information May 2001, Vol.43, No.5, p.474-482. 29 ref.
Abstract N,N-Dimethylformamide (DMF) has excellent solvent properties and is used intensively in the production of synthetic leather and resins. It has caused hepatoxicity in human and animal studies. Hepatitis B virus (HBV) and hepatitis C virus infections are reported to be the major causes of chronic liver diseases (including liver cirrhosis and liver cancer) in Taiwan. This study examined the dose-response relationship of the observed abnormal liver function among the DMF-exposed workers and the interactions among DMF, other chemical exposures, HBV infection, and potential confounders on liver abnormalities. It was observed that a significant dose-response relationship existed between liver function abnormalities and DMF exposure among workers in Taiwan, and that HBV carrier status or increased BMI had synergistic effects with DMF exposure in causing liver abnormalities (abnormal liver function tests and clinical chronic liver diseases).
Descriptors (primary) hepatotoxic effects; infectious hepatitis; dimethylformamide
Descriptors (secondary) dose-response relationship; Taiwan (China)
Document type D - Periodical articles
Country / State or ProvinceTaiwan (China)
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Liver diseases
Bacterial and parasitic diseases
Viral diseases (other than aids)