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Document ID (ISN)78505
CIS number 02-709
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 2000
Convention or series no.
Author(s) Kristensen P., Andersen A., Irgens L.M.
Title Hormone-dependent cancer and adverse reproductive outcomes in farmers' families - Effects of climatic conditions favoring fungal growth in grain
Bibliographic information Aug. 2000, Vol.26, No.4, p.331-337. 24 ref.
Abstract The impact of grain farming and climate on late-term abortion among female farmers, male genital birth defects among their sons, and hormone-dependent cancer among male and female farmers and their adult children was investigated. 246,043 male and female farmers born between 1925 and 1971 and 264,262 of their offspring were identified from the Norwegian national registers. Categories of high exposure were associated with adverse reproductive outcomes and cancer among female farmers, the strongest occurring for late-term abortion (Odds Ratio (OR) 2.6). Exposure associations for ovarian and breast cancer, and male genital defects, were more moderate. Endometrial cancer was associated with grain farming (OR 2.0). Exposure associations for cancer were strongest for pre-menopausal, parous women. The results are consistent with hormonal effects of inhaled mycotoxins during pregnancy.
Descriptors (primary) cereal farming; antifertility effects; cancer; hormones; mycotoxins
Descriptors (secondary) climate; ovarian cancer; Norway; children; diseases of genital organs; carcinogenic effects; uterine cancer; breast cancer; cohort study; short-term exposure; expectant mothers; abortion
Document type D - Periodical articles
Country / State or ProvinceNorway
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s) Industries and occupations
Browse category(ies) Antifertility and prenatal effects
Agriculture
Genetic factors in reaction to exposures