| Document ID (ISN) | 78504 |
| CIS number |
02-811 |
| ISSN - Serial title |
0355-3140 - Scandinavian Journal of Work, Environment and Health |
| Year |
2000 |
| Convention or series no. |
|
| Author(s) |
Stayner L.T., Dankovic D.A., Smith R.J., Gilbert S.J., Bailer A.J. |
| Title |
Human cancer risk and exposure to 1,3-butadiene - A tale of mice and men |
| Bibliographic information |
Aug. 2000, Vol.26, No.4, p.322-330. Illus. 36 ref. |
| Abstract |
The purpose of this study was to evaluate empirically the relevance of animal-bioassay-based models for predicting human risks from exposure to 1,3-butadiene (BD) using epidemiological data. Relative-risk results obtained with a regression model in a recent epidemiological study were used to estimate leukaemia risk for occupational and environmental exposures to BD and to compare these estimates with those previously derived from an analysis of animal bioassay data. The estimates of risk were found to be highly dependent on the model used when low levels of exposure were evaluated that are of environmental concern, but not at the levels of occupational concern. |
| Descriptors (primary) |
leukaemia; butadiene; prediction; health hazards; hazard evaluation |
| Descriptors (secondary) |
epidemiology; mathematical models; human experiments; animal experiments |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Butadiene
Risk evaluation
Leukaemia
Aliphatic and alicyclic hydrocarbons
|
