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Document ID (ISN)78504
CIS number 02-811
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 2000
Convention or series no.
Author(s) Stayner L.T., Dankovic D.A., Smith R.J., Gilbert S.J., Bailer A.J.
Title Human cancer risk and exposure to 1,3-butadiene - A tale of mice and men
Bibliographic information Aug. 2000, Vol.26, No.4, p.322-330. Illus. 36 ref.
Abstract The purpose of this study was to evaluate empirically the relevance of animal-bioassay-based models for predicting human risks from exposure to 1,3-butadiene (BD) using epidemiological data. Relative-risk results obtained with a regression model in a recent epidemiological study were used to estimate leukaemia risk for occupational and environmental exposures to BD and to compare these estimates with those previously derived from an analysis of animal bioassay data. The estimates of risk were found to be highly dependent on the model used when low levels of exposure were evaluated that are of environmental concern, but not at the levels of occupational concern.
Descriptors (primary) leukaemia; butadiene; prediction; health hazards; hazard evaluation
Descriptors (secondary) epidemiology; mathematical models; human experiments; animal experiments
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Leukaemia
Aliphatic and alicyclic hydrocarbons
Butadiene
Risk evaluation