|Document ID (ISN)||78368|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Rice F.L., Park R., Stayner L., Smith R., Gilbert S., Checkoway H.
||Crystalline silica exposure and lung cancer mortality in diatomaceous earth industry workers: A quantitative risk assessment
||Jan. 2001, Vol.58, No.1, p.38-45. Illus. 43 ref.
||Data from a cohort mortality study of 2342 white male California diatomaceous earth mining and processing workers exposed to crystalline silica dust (mainly cristobalite) were analyzed using different exposure-response models. Exposure to respirable crystalline silica dust was a significant predictor in nearly all of the models evaluated and the linear relative rate model with a 10-year exposure lag seemed to give the best fit in the Poisson regression analysis. For those who died of lung cancer, the linear relative rate model predicted rate ratios for mortality from lung cancer of about 1.6 for the mean cumulative exposure to respirable silica compared with no exposure. Results show that a male worker exposed to 0.05mg/m3 of respirable silica dust containing cristobalite over a 45 year working lifetime has an increase in lifetime risk of lung cancer of about 2%. The predicted number of deaths from lung cancer suggests that current occupational health standards may not be adequately protecting workers from the risk of lung cancer.
||diatomaceous earth; silica; hazard evaluation; lung cancer; mortality
||cristobalite; mathematical models; cohort study
||D - Periodical articles
|Country / State or Province||USA|
|Broad subject area(s)
Diseases of the respiratory system (except for pneumoconiosis & similar)