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Document ID (ISN)78368
CIS number 02-803
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2001
Convention or series no.
Author(s) Rice F.L., Park R., Stayner L., Smith R., Gilbert S., Checkoway H.
Title Crystalline silica exposure and lung cancer mortality in diatomaceous earth industry workers: A quantitative risk assessment
Bibliographic information Jan. 2001, Vol.58, No.1, p.38-45. Illus. 43 ref.
Abstract Data from a cohort mortality study of 2342 white male California diatomaceous earth mining and processing workers exposed to crystalline silica dust (mainly cristobalite) were analyzed using different exposure-response models. Exposure to respirable crystalline silica dust was a significant predictor in nearly all of the models evaluated and the linear relative rate model with a 10-year exposure lag seemed to give the best fit in the Poisson regression analysis. For those who died of lung cancer, the linear relative rate model predicted rate ratios for mortality from lung cancer of about 1.6 for the mean cumulative exposure to respirable silica compared with no exposure. Results show that a male worker exposed to 0.05mg/m3 of respirable silica dust containing cristobalite over a 45 year working lifetime has an increase in lifetime risk of lung cancer of about 2%. The predicted number of deaths from lung cancer suggests that current occupational health standards may not be adequately protecting workers from the risk of lung cancer.
Descriptors (primary) diatomaceous earth; silica; hazard evaluation; lung cancer; mortality
Descriptors (secondary) cristobalite; mathematical models; cohort study
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Risk evaluation
Diseases of the respiratory system (except for pneumoconiosis & similar)