| Document ID (ISN) | 78350 |
| CIS number |
02-301 |
| ISSN - Serial title |
0271-3586 - American Journal of Industrial Medicine |
| Year |
2001 |
| Convention or series no. |
|
| Author(s) |
Page E.H., Pajeau A.K., Arnold T.C., Fincher A.R., Goddard M.J. |
| Title |
Peripheral neuropathy in workers exposed to nitromethane |
| Bibliographic information |
July 2001, Vol.40, No.1, p.107-113. 33 ref. |
| Abstract |
Two workers from a headlight subassembly plant developed severe peripheral neuropathy. These workers had extensive, but brief (1-2 months), dermal and inhalation exposure to nitromethane, a solvent. Environmental sampling was performed for nitromethane and ethyl cyanoacrylate. Medical records, including electrodiagnostic studies, were reviewed. Literature on nitromethane, ethyl cyanoacrylate, and other exposures in the workplace was reviewed. Electromyography and nerve conduction studies performed on these patients were consistent with a severe, axonal neuropathy. No aetiology was discovered despite an extensive medical evaluation. Environmental sampling revealed exposure to nitromethane at the threshold limit value. The history of acute onset of severe peripheral neuropathy temporally associated with exposure to nitromethane is suggestive of a toxic neuropathy. While it cannot be definitively concluded that these two workers developed peripheral neuropathy secondary to exposures at work, occupational exposure to nitromethane appears to be the most likely aetiology. |
| Descriptors (primary) |
neurotoxic effects; diseases of peripheral nervous system; nitromethane |
| Descriptors (secondary) |
case study; determination in air; methyl cyanoacrylate; ethyl 2-cyanoacrylate |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Diseases of the nervous system
Aliphatic nitro compounds
|
