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CISDOC database

Document ID (ISN)78170
CIS number 02-337
Year 2002
Convention or series no. ECETOC Technical Report No.83
Title The use of T25 estimates and alternative methods in the regulatory risk assessment of non-threshold carcinogens in the European Union
Bibliographic information European Centre for Ecotoxicology and Toxicology of Chemicals, Avenue E. Van Nieuwenhuyse 4, Bte. 6, 1160 Bruxelles, Belgium, Jan. 2002. 35p. Illus. 33 ref.
Abstract In the European Union, new and existing chemical substances are required to undergo a regulatory risk assessment and where the hazard of carcinogenicity exists, this should be taken into account. A simplified method for this assessment, the T25 estimation, has been proposed for estimating carcinogenic potency from the results of animal experiments, which estimates the dose of carcinogen that will produce cancer in 25% of the animals that would not have developed cancer spontaneously. A human HT25 is the derived. This document discusses this proposal and other alternative methods.
Descriptors (primary) hazard evaluation; carcinogens
Descriptors (secondary) literature survey; threshold limit values; animal experiments; European Communities; evaluation of technique; report
Document type E - Books, reports, proceedings
Country / State or ProvinceBelgium
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Risk evaluation