ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)78150
CIS number 02-289
ISSN - Serial title 1219-1221 - Central European Journal of Occupational and Environmental Medicine
Year 2000
Convention or series no.
Author(s) Major J., Jakab M.G., Tompa A.
Title HPRT mutation frequencies in benzene-exposed oil refinery workers during an eleven-year-long follow-up study
Bibliographic information 2000, Vol.6, No.4, p.288-299. Illus. 45 ref.
Abstract Mutation and variant frequencies (VF) of the hypoxanthine-guanine-phosphoribosyl-transferase (HPRT) loci of peripheral blood lymphocytes (PBL) of 43 occupationally benzene-exposed, 30-40-year-old workers with increased chromosome aberration frequencies were investigated by autoradiography in an eleven-year-long follow-up study in order to assess the cancer risk. Data were compared to those of 87 age-matched controls. Ambient air benzene concentrations were measured with gas chromatography. Compared to the controls, the values of the labelling indices in PBLs of the exposed donors were decreased indicating a reduced response to lectine stimulation in the genotoxicologically compromised cells. In the years 1992-1993, the mean hprt VFs of the exposed workers were significantly higher than those of the controls, but not in the previous or subsequent years. The distribution of the individual VFs also indicated exposure-related increases in the years 1991-1993. The data indicate that occupational exposure to benzene can increase the cell mutation frequencies.
Descriptors (primary) mutagenic effects; petroleum refining; hazard evaluation; benzene
Descriptors (secondary) lymphocytes; exposure evaluation; frequency rates; long-term study; case-control study
Document type D - Periodical articles
Country / State or ProvinceHungary
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Risk evaluation
Aromatic hydrocarbons
Petroleum and natural gas industry
Petrochemical industry
Genetic factors in reaction to exposures