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Document ID (ISN)78149
CIS number 02-288
ISSN - Serial title 1219-1221 - Central European Journal of Occupational and Environmental Medicine
Year 2000
Convention or series no.
Author(s) Cebulska-Wasilewska A., Wierzewska A., Dyga W., Drąg Z., Siffel C., Horváth M., Au W.
Title Induction of DNA and cytogenic damage in lymphocytes of Polish workers exposed to pesticides
Bibliographic information 2000, Vol.6, No.4, p.272-287. Illus. 18 ref.
Abstract This paper presents preliminary data from the Polish subgroup of a joint research program (Greece, Hungary, Poland, and Spain) investigating the relationship between exposure to agrochemicals and the induction of genotoxicity in human cells. Blood samples were collected from male donors (50 persons in a reference group and 50 persons in a group occupationally exposed to pesticides). The collected samples were analysed for the induction of DNA strand breaks and of chromosome damage. Analysis of the data from the interviews revealed that the occupationally exposed group showed significantly higher frequency of some health problems (cardiovascular disorders, kidney, neurological and dermatological problems, infections). The exposed group also had higher levels of DNA damage and sister chromatid exchanges compared to the reference group. It was also found that cigarette smoking played an important role influencing the biomarker response. Although the farmers in Poland have been using safety devices when handling pesticides, more rigorous procedures need to be employed.
Descriptors (primary) Poland; DNA; exposure tests; genetic effects; agriculture; pesticides
Descriptors (secondary) smoking; determination in blood; chromosome changes; case-control study
Document type D - Periodical articles
Country / State or ProvinceHungary; Poland; USA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Agricultural chemicals
Genetic factors in reaction to exposures
Biological monitoring
Antifertility and prenatal effects