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Document ID (ISN)78058
CIS number 02-188
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2001
Convention or series no.
Author(s) Hodgson M.J., Bracker A., Yang C., Storey E., Jarvis B.J., Milton D., Lummus Z., Bernstein D., Cole S.
Title Hypersensitivity pneumonitis in a metal-working environment
Bibliographic information June 2001, Vol.39, No.6, p.616-628. 53 ref.
Abstract Following an outbreak of lung disease among workers in a metal-working plant, a study was conducted involving the clinical examination of patients, a cross-sectional questionnaire survey of the outbreak plant and two control plant areas (with and without metal-working fluids (MWF) exposures), an industrial hygiene survey with laboratory characterization of microbial flora, and immunological investigations. 39 (79.6%) patients described symptoms consistent with work-related lung disease, and 8 received other diagnoses. Sixteen had hypersensitivity pneumonitis confirmed on biopsy. Mean decrements in lung forced expiratory volume in 1s and forced vital capacity from before to after work were similar in the 16 biopsy-confirmed cases of hypersensitivity pneumonitis and the 19 symptomatic patients without biopsies. Three sources of water-based aerosols were identified that grew similar microbial flora, but antibody testing did not identify a specific single organism. Endotoxin levels were similar in the outbreak and the MWF control plant.
Descriptors (primary) cutting fluids; allergic respiratory disorders; metalworking industry
Descriptors (secondary) allergens; microorganisms; exposure evaluation; respiratory function tests; cross-sectional study; histopathology; questionnaire survey
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Metal production and metalworking
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Metalworking industry