|Document ID (ISN)||78058|
|ISSN - Serial title
||0271-3586 - American Journal of Industrial Medicine
|Convention or series no.
||Hodgson M.J., Bracker A., Yang C., Storey E., Jarvis B.J., Milton D., Lummus Z., Bernstein D., Cole S.
||Hypersensitivity pneumonitis in a metal-working environment
||June 2001, Vol.39, No.6, p.616-628. 53 ref.
||Following an outbreak of lung disease among workers in a metal-working plant, a study was conducted involving the clinical examination of patients, a cross-sectional questionnaire survey of the outbreak plant and two control plant areas (with and without metal-working fluids (MWF) exposures), an industrial hygiene survey with laboratory characterization of microbial flora, and immunological investigations. 39 (79.6%) patients described symptoms consistent with work-related lung disease, and 8 received other diagnoses. Sixteen had hypersensitivity pneumonitis confirmed on biopsy. Mean decrements in lung forced expiratory volume in 1s and forced vital capacity from before to after work were similar in the 16 biopsy-confirmed cases of hypersensitivity pneumonitis and the 19 symptomatic patients without biopsies. Three sources of water-based aerosols were identified that grew similar microbial flora, but antibody testing did not identify a specific single organism. Endotoxin levels were similar in the outbreak and the MWF control plant.
||cutting fluids; allergic respiratory disorders; metalworking industry
||allergens; microorganisms; exposure evaluation; respiratory function tests; cross-sectional study; histopathology; questionnaire survey
||D - Periodical articles
|Country / State or Province||USA|
||Metal production and metalworking
|Broad subject area(s)
||Occupational medicine, epidemiology
||Diseases of the respiratory system (except for pneumoconiosis & similar)