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CISDOC database

Document ID (ISN)78055
CIS number 02-313
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2001
Convention or series no.
Author(s) Redlich C.A., Stowe M.H., Wisnewski A.V., Eisen E.A., Karol M.H., Lemus R., Holm C.T., Chung J.S., Sparer J., Liu Y., Woskie S.R., Appiah-Pippim J., Gore R., Cullen M.R.
Title Subclinical immunologic and physiologic responses in hexamethylene diisocyanate-exposed auto body shop workers
Bibliographic information June 2001, Vol.39, No.6, p.587-597. Illus. 31 ref.
Abstract Diisocyanates are potent sensitizing agents and a frequently identified cause of occupational asthma. A cross-sectional field epidemiologic study was conducted to characterize the effects of hexamethylene diisocyanate (HDI) exposures on auto body shop workers. Data on the 75 subjects enrolled in the study were collected by questionnaire and physiological testing. No overt cases of clinically apparent diisocyanate asthma were identified based on spirometry, methacholine challenge, peak flows, and symptoms. HDI-specific lymphocyte proliferation was present in 30% of HDI-exposed workers and HDI-specific IgG in 34% of HDI-exposed workers, but they were not associated. HDI-specific IgE was detected in two workers. HDI-specific lymphocyte proliferation, increased methacholine responsiveness, and symptoms of chest tightness and shortness of breath were more common in the most heavily HDI-exposed workers, the painters. These findings demonstrate the presence of HDI-specific immune responses in a large proportion of healthy HDI-exposed workers.
Descriptors (primary) hexamethylene diisocyanate; coachwork; immunology; asthma
Descriptors (secondary) immunoglobulins; respiratory function tests; cross-sectional study; questionnaire survey
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Metal production and metalworking
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Isocyanates
Cyano compounds
Motor vehicle manufacturing industry