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Document ID (ISN)78048
CIS number 02-296
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2000
Convention or series no.
Author(s) Laforest L., Luce D., Goldberg P., Bégin D., Guérin M., Demers P.A., Brugère J., Leclerc A.
Title Laryngeal and hypopharyngeal cancers and occupational exposure to formaldehyde and various dusts: A case-control study in France
Bibliographic information Nov. 2000, Vol.57, No.11, p.767-773. 51 ref.
Abstract To assess possible associations between occupational exposures and squamous cell carcinomas of the larynx and hypopharynx, a case-control study was carried out on 201 cases with hypopharyngeal cancers, 296 cases with laryngeal cancers and 296 controls (patients with other tumour sites). Detailed information on smoking, alcohol consumption, and lifetime occupational history was collected. Occupational exposure to formaldehyde, leather dust, wood dust, flour dust, coal dust, silica dust and textile dust was assessed with a job exposure matrix. Hypopharyngeal cancer was found to be associated with exposure to coal dust (odds ratio (OR) 2.31), with a significant rise in risk with probability and level of exposure. Exposure to coal dust was also associated with an increased risk of laryngeal cancer (OR 1.67). A significant relation, limited to hypopharyngeal cancer, was found with the probability of exposure to formaldehyde, with a fourfold risk for the highest category (OR 3.78).
Descriptors (primary) formaldehyde; respirable dust; pharyngeal cancer; laryngeal cancer
Descriptors (secondary) coal dust; France; job-exposure relation; case-control study; hazard evaluation
Document type D - Periodical articles
Country / State or ProvinceCanada; France
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Aldehydes
Diseases of the respiratory system (except for pneumoconiosis & similar)