|Document ID (ISN)||77685|
|ISSN - Serial title
||1061-0251 - Occupational Hygiene
|Convention or series no.
||Lňstbom L., Camner P., Ryrfeldt ┼.
||Acute lung function impairment by hexamethylene diisocyanate and toluene diisocyanate - A comparative study using isolated guinea pig lungs
||1999, Vol.5, No.2, p.111-120. Illus. 20 ref.
||Isolated, perfused and ventilated guinea pig lungs were exposed, through the airways, to two concentrations of toluene diisocyanate, TDI (21.7 and 25.2mg/m3) and hexamethylene diisocyanate, HDI (12 and 26.3mg/m3). At the low concentrations, both TDI and HDI caused a moderate decrease in conductance, Gaw (approx. 17%) and compliance, Cdyn (approx. 8%) after one hour of exposure. However, at the high concentrations, HDI caused a much sharper decrease in lung function (approx. 84% for Gaw and approx. 73% for Cdyn) than TDI (approx. 28% for Gaw and approx. 22% for Cdyn). Neither TDI nor HDI caused any effect on the perfusion flow. It is concluded that HDI is 2-3.5 times more potent than TDI to induce bronchoconstriction in the isolated perfused guinea pig lung.
||hexamethylene diisocyanate; respiratory impairment; pulmonary function; tolylene diisocyanate
||bronchoconstrictors; animal experiments; lung conductance
||D - Periodical articles
|Country / State or Province||Sweden|
|Broad subject area(s)
||Diseases of the respiratory system (except for pneumoconiosis & similar)