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Document ID (ISN)77685
CIS number 01-1762
ISSN - Serial title 1061-0251 - Occupational Hygiene
Year 1999
Convention or series no.
Author(s) Lňstbom L., Camner P., Ryrfeldt ┼.
Title Acute lung function impairment by hexamethylene diisocyanate and toluene diisocyanate - A comparative study using isolated guinea pig lungs
Bibliographic information 1999, Vol.5, No.2, p.111-120. Illus. 20 ref.
Abstract Isolated, perfused and ventilated guinea pig lungs were exposed, through the airways, to two concentrations of toluene diisocyanate, TDI (21.7 and 25.2mg/m3) and hexamethylene diisocyanate, HDI (12 and 26.3mg/m3). At the low concentrations, both TDI and HDI caused a moderate decrease in conductance, Gaw (approx. 17%) and compliance, Cdyn (approx. 8%) after one hour of exposure. However, at the high concentrations, HDI caused a much sharper decrease in lung function (approx. 84% for Gaw and approx. 73% for Cdyn) than TDI (approx. 28% for Gaw and approx. 22% for Cdyn). Neither TDI nor HDI caused any effect on the perfusion flow. It is concluded that HDI is 2-3.5 times more potent than TDI to induce bronchoconstriction in the isolated perfused guinea pig lung.
Descriptors (primary) hexamethylene diisocyanate; respiratory impairment; pulmonary function; tolylene diisocyanate
Descriptors (secondary) bronchoconstrictors; animal experiments; lung conductance
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Isocyanates
Cyano compounds