|Document ID (ISN)||77534|
|Convention or series no.
Inter-Organization Programme for the Sound Management of Chemicals (IOMC)
||1,3-Butadiene: Human health aspects
||World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 2001. iv, 73p. Illus. 256 ref. Price: CHF 21.00 (CHF 14.70 in developing countries).
||http://www.who.int/ipcs/publications/cicad/en/cicad30.pdf [in English]
||1,3-Butadiene is a product of incomplete combustion resulting from natural processes and human activity, as well as an industrial chemical used primarily in the production of elastomers. It has low acute toxicity in experimental animals. In studies involving mice and rats, long-term exposure was associated with ovarian and testicular atrophy; inhaled butadiene was found to be a potent carcinogen and to show mutagenic effects. Among exposed workers, mortality due to leukaemia increased with estimated cumulative exposure. The available epidemiological and toxicological data provide evidence that butadiene is a human carcinogen, and possibly also a genotoxic agent. IARC has classified butadiene in group 2A (probably carcinogenic to humans). Summaries in French and in Spanish.
||IPCS; toxicology; butadiene
||toxic effects; literature survey; leukaemia; ILO; UNEP; criteria document; ecotoxicology; animal experiments; lethal concentration 50; genetic effects; carcinogenic effects; WHO
||B - Chemical safety information sheets
|Country / State or Province||WHO|
||Toxic and dangerous substances
|Broad subject area(s)
||Genetic factors in reaction to exposures
Aliphatic and alicyclic hydrocarbons