|Document ID (ISN)||77427|
|ISSN - Serial title
||0003-4878 - Annals of Occupational Hygiene
|Convention or series no.
||A tape-stripping method for measuring dermal exposure to multifunctional acrylates
||Dec. 2000, Vol.44, No.8, p.645-651. Illus. 32 ref.
||A noninvasive sampling method was developed and tested for measuring dermal exposure to a multifunctional acrylate employing a tape stripping of the nonviable epidermis (stratum corneum). Samples were subsequently extracted and a gas-chromatographic method was employed for quantitative analysis of tripropylene glycol diacrylate (TPGDA). This method was tested in 10 human volunteers exposed either to a known level of TPGDA or to a UV-radiation curable acrylate coating containing TPGDA (UV-resin). On the average, the first tape stripping removed 94% (coefficient of variation 16%) of the theoretical quantity of deposited TPGDA in the first group and 89% (coefficient of variation 15%) in the second group. Quantities of TPGDA recovered from two consecutive tape strippings accounted for all of the test agent, demonstrating both the efficiency of the method to measure dermal exposure and the potential to determine the rate of absorption with successive samples over time. The results indicate that this tape-stripping technique can be used to quantify dermal exposure to multifunctional acrylates.
||acrylates; skin tests; skin absorption
||sampling methods; tripropylene glycol diacrylate; gas chromatography; description of technique
||D - Periodical articles
|Country / State or Province||USA|
|Broad subject area(s)