|Document ID (ISN)||77424|
|ISSN - Serial title
||0003-4878 - Annals of Occupational Hygiene
|Convention or series no.
||Hodgson J.T., Darnton A.
||The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure
||Dec. 2000, Vol.44, No.8, p.565-601. Illus. 73 ref.
||Mortality reports on asbestos-exposed cohorts which gave information on exposure levels from which (as a minimum) a cohort average cumulative exposure could be estimated were reviewed. At exposure levels seen in occupational cohorts it is concluded that the exposure specific risk of mesothelioma from three principal commercial asbestos types is broadly in the ratio 1:100:500 for chrysotile, amosite and crocidolite, respectively. For lung cancer the conclusions are less clear cut. Cohorts exposed only to crocidolite or amosite record similar exposure specific risk levels, but chrysotile-exposed cohorts show a less consistent picture. An excess risk is recorded by cohorts with mixed fibre exposures (generally <1%). It is suggested that a best estimate lung cancer risk for chrysotile alone would be 0.1%, with a highest reasonable estimate of 0.5%. The risk differential between chrysotile and the two amphibole fibres for lung cancer is thus between 1:10 and 1:50. Based on these considerations, and a discussion of the associated uncertainties, a series of quantified risk summary statements for different levels of cumulative exposure are presented.
||literature survey; mesothelioma; hazard evaluation; mortality; lung cancer; asbestos
||amosite; chrysotile; dose-response relationship; long-term exposure; crocidolite
||D - Periodical articles
|Country / State or Province||United Kingdom|
||Dust, aerosols and related diseases
|Broad subject area(s)
||Diseases of the respiratory system (except for pneumoconiosis & similar)