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Document ID (ISN)77424
CIS number 01-1462
ISSN - Serial title 0003-4878 - Annals of Occupational Hygiene
Year 2000
Convention or series no.
Author(s) Hodgson J.T., Darnton A.
Title The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure
Bibliographic information Dec. 2000, Vol.44, No.8, p.565-601. Illus. 73 ref.
Abstract Mortality reports on asbestos-exposed cohorts which gave information on exposure levels from which (as a minimum) a cohort average cumulative exposure could be estimated were reviewed. At exposure levels seen in occupational cohorts it is concluded that the exposure specific risk of mesothelioma from three principal commercial asbestos types is broadly in the ratio 1:100:500 for chrysotile, amosite and crocidolite, respectively. For lung cancer the conclusions are less clear cut. Cohorts exposed only to crocidolite or amosite record similar exposure specific risk levels, but chrysotile-exposed cohorts show a less consistent picture. An excess risk is recorded by cohorts with mixed fibre exposures (generally <1%). It is suggested that a best estimate lung cancer risk for chrysotile alone would be 0.1%, with a highest reasonable estimate of 0.5%. The risk differential between chrysotile and the two amphibole fibres for lung cancer is thus between 1:10 and 1:50. Based on these considerations, and a discussion of the associated uncertainties, a series of quantified risk summary statements for different levels of cumulative exposure are presented.
Descriptors (primary) literature survey; mesothelioma; hazard evaluation; mortality; lung cancer; asbestos
Descriptors (secondary) amosite; chrysotile; dose-response relationship; long-term exposure; crocidolite
Document type D - Periodical articles
Country / State or ProvinceUnited Kingdom
Subject(s) Dust, aerosols and related diseases
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Risk evaluation