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CISDOC database

Document ID (ISN)77311
CIS number 01-1461
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2000
Convention or series no.
Author(s) Finkelstein M.M.
Title Silica, silicosis, and lung cancer: A risk assessment
Bibliographic information July 2000, Vol.38, No.1, p.8-18. 26 ref.
Abstract To investigate exposure-response relationships for silica, silicosis and lung cancer, a quantitative review of the literature identified in a computerized literature search was carried out. The findings of the most significant studies are that the risk of silicosis following a lifetime of exposure at the current OSHA standard of 0.1mg/m3 is likely to be at least 5-10% and lung cancer risk is likely to be increased by 30% or more. The exposure-response relationship for silicosis is nonlinear and reduction of dust exposures would have a greater than linear benefit in terms of risk reduction; available data suggests that 30 years exposure at 0.1mg/m3 might lead to a lifetime silicosis risk of about 25%, whereas reduction of the exposure to 0.05mg/m3 might reduce the risk to under 5%. In conclusion, the lifetime risk of silicosis and lung cancer at an exposure level of 0.1mg/m3 is high. Lowering exposures to the NIOSH recommended limit if 0.05mg/m3 may have substantial benefits.
Descriptors (primary) silica; lung cancer; long-term exposure; hazard evaluation; silicosis
Descriptors (secondary) literature survey; dose-response relationship; respirable dust
Document type D - Periodical articles
Country / State or ProvinceCanada
Subject(s) Dust, aerosols and related diseases
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Risk evaluation
Pneumoconioses