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CISDOC database

Document ID (ISN)77269
CIS number 01-1459
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2000
Convention or series no.
Author(s) Hessel P.A., Gamble J.F., Gee J.B.L., Gibbs G., Green F.H.Y., Morgan W.K.C., Mossman B.T.
Title Silica, silicosis, and lung cancer: A response to a recent working group report
Bibliographic information July 2000, Vol.42, No.7, p.704-720. Illus. 84 ref.
Abstract On the basis of numerous studies on crystalline silica and lung cancer, IARC has determined that there was sufficient evidence to conclude that quartz and cristobalite were carcinogenic in humans. However, the results of these studies are inconsistent and, when positive, only weakly positive. Other, methodologically strong, negative studies have not been considered. Several studies viewed as providing evidence supporting the carcinogenicity of silica have significant methodological weaknesses. Silica is not directly genotoxic and is a pulmonary carcinogen only in the rat, a species inappropriate for assessing carcinogenesis in humans. Data on humans show a lack of association between lung cancer and exposure to crystalline silica. Studies in which silicotic patients were not identified from compensation registries, and in which enumeration was complete, did not support a causal association between silicosis and lung cancer, which further argues against the carcinogenicity of crystalline silica.
Descriptors (primary) carcinogens; silica; hazard evaluation; silicosis; lung cancer
Descriptors (secondary) literature survey; quartz; IARC; cristobalite
Document type D - Periodical articles
Country / State or ProvinceCanada; USA
Subject(s) Dust, aerosols and related diseases
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Risk evaluation
Pneumoconioses