|Document ID (ISN)||77262|
|ISSN - Serial title
||0271-3586 - American Journal of Industrial Medicine
|Convention or series no.
||Douwes J., Wouters I., Dubbeld H., van Zwieten L., Steerenberg P., Doekes G., Heederik D.
||Upper airway inflammation assessed by nasal lavage in compost workers: A relation with bio-aerosol exposure
||May 2000, Vol.37, No.5, p.459-468. Illus. 21 ref.
||Exposure to microbial agents in the composting industry may cause work-related airway inflammation. Nasal lavage (NAL) has been proposed as a noninvasive method to assess such effects in population studies. Pre- and post-shift NAL were performed in the workers of a compost plant and in controls. Total cells, cytokines and other inflammation markers were measured in NAL fluid, and pre-shift levels and post/pre concentration ratios were compared with NAL results obtained in the controls. Job-title specific exposure levels ranged from 29 to 527EU/m3 for endotoxin and from 0.36 to 4.85µg/m3 for β(1,3)-glucan. Pre-shift NAL concentrations of total cells, myeloperoxydase, interleukin-8, NO and albumin and post/pre ratios for various markers were significantly higher in compost workers than in controls. NAL cells were mainly neutrophils. It is concluded that occupational exposure of compost workers may cause acute or chronic reactions in the upper airways induced by inflamatory agents such as endotoxins and β(1,3)-glucan.
||microorganisms; garbage composting; upper respiratory diseases; bacterial toxins
||inflammations; determination in biological matter; exposure evaluation
||D - Periodical articles
|Country / State or Province||Netherlands|
|Broad subject area(s)
||Waste collection and disposal
Diseases of the respiratory system (except for pneumoconiosis & similar)