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CISDOC database

Document ID (ISN)76961
CIS number 01-1115
ISSN - Serial title 0003-4878 - Annals of Occupational Hygiene
Year 2000
Convention or series no.
Author(s) Soutar C.A., Robertson A., Miller B.G., Searl A., Bignon J.
Title Epidemiological evidence on the carcinogenicity of silica: Factors in scientific judgement
Bibliographic information Jan. 2000, Vol.44, No.1, p.3-14. 69 ref.
Abstract In view of the extended debate and differing opinions on whether crystalline silica is a human carcinogen, a selection of epidemiological reports was reviewed in order to identify the areas of uncertainty and disagreement. Papers which in a recent review were considered to provide the least confounded examinations of an association between silica exposure and cancer risk have been examined together with a study of the mortality of coalminers. It has been found that parts of the evidence were coherent but there were contradictions. On examination, this resolved mostly into differences between types of studies. The three types of epidemiological study included were: exposure-response studies, studies in which incidence of disease in an exposed population is compared with that in a reference population and studies of incidence of disease in subjects on silicosis case-registers. Scientific uncertainties in the evidence (confounders, bias, false assumptions) are discussed.
Descriptors (primary) silica; carcinogenic effects; lung cancer; epidemiology
Descriptors (secondary) literature survey; cristobalite; European Communities; IARC; classification; occupation disease relation; silicosis; dose-response relationship; quartz
Document type D - Periodical articles
Country / State or ProvinceFrance; United Kingdom
Subject(s) Dust, aerosols and related diseases
Broad subject area(s) Chemical safety
Browse category(ies) Epidemiology
Diseases of the respiratory system (except for pneumoconiosis & similar)