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Document ID (ISN)76787
CIS number 01-850
ISSN - Serial title 1877-7856 - Encyclopédie médico-chirurgicale
Year 1999
Convention or series no. Fascicule 16-002-F-10
Author(s) Flesch F., Thaon I.
Title Iron poisoning
Original title Intoxications par le fer [in French]
Bibliographic information Toxicologie-Pathologie professionnelle, 2nd Quarter 1999, No.123, 4p. 28 ref.
Abstract Most cases of acute poisoning by iron are due to the ingestion of ferrous salts, either accidentally among children, or more rarely with an intention of committing suicide among adults. The main toxic mechanism of iron derives from its ability to induce the formation of free radicals and, consequently, the peroxidization of lipids. Iron poisoning evolves through four phases: digestive problems; transient clinical improvement; hepatitis; shock and acidosis; permanent after-effects on the digestive system in the form of stenosis. Besides symptomatic treatment, the treatment involves decontamination of the digestive tract, including intestinal lavage and chelating treatment with deferoxamine. Activated carbon is not effective. Chronic exposure to iron occurs mainly in occupational settings, and gives rise to overload pneumoconiosis due to the inhalation of iron oxide dust.
Descriptors (primary) poisoning; toxicology; France; iron and compounds
Descriptors (secondary) iron oxide; acute toxicity; free radicals; deferoxamine; ingestion; data sheet; dust; hard metal pneumoconiosis; antidote treatment; chronic toxicity; encyclopaedia; inhalation
Document type F - Information notes, codes of practice, standards
Country / State or ProvinceFrance
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Iron and compounds
Inorganic substances