| Document ID (ISN) | 76652 |
| CIS number |
01-825 |
| ISSN - Serial title |
0025-7818 - Medicina del lavoro |
| Year |
2000 |
| Convention or series no. |
|
| Author(s) |
Imbriani M., Marraccini P., Saretto G., Abatangelo L., Ghittori S., Cavalleri A. |
| Title |
Determination of N-methylformamide following occupational exposure to N,N-dimethylformamide |
| Original title |
Il dosaggio della N-metilformamide nella esposizione professionale a N,N-dimetilformamide [in Italian] |
| Bibliographic information |
Mar.-Apr. 2000, Vol.91, No.2, p.114-124. Illus. 29 ref. |
| Abstract |
To evaluate the correlation between the excretion of N-methylformamide (NMF) and levels of exposure to N,N-dimethylformamide (DMF) among occupationally exposed persons, 25 male workers aged between 25 and 54 in a synthetic leather factory were studied daily over a 5-day period. The mean time-weighted average (TWA) exposure was about half (13.5mg/m3) of the current threshold limit value, the range of the values varying from 0.4 to 75.2mg/m3. A linear equation existed between urinary NMF concentration and DMF concentration in the environment. The findings show that the urinary NMF concentration can be used as an appropriate biological exposure index. For occupationally exposed subjects, a urinary NMF concentration corresponding to the time-weighted average of the threshold limit value of 39.9mg/L (37.2mg/g creatinine) and a 95% lower confidence limit (biological threshold) of 23.4mg/L (22.2mg/g creatinine) are suggested. |
| Descriptors (primary) |
methylformamide; exposure tests; plastics converting industry; dimethylformamide |
| Descriptors (secondary) |
threshold limit values; creatinine; determination in urine; exposure evaluation; urinary excretion |
| Document type |
D - Periodical articles |
| Country / State or Province | Italy |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Biological monitoring
Amides
|
