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Document ID (ISN)76652
CIS number 01-825
ISSN - Serial title 0025-7818 - Medicina del lavoro
Year 2000
Convention or series no.
Author(s) Imbriani M., Marraccini P., Saretto G., Abatangelo L., Ghittori S., Cavalleri A.
Title Determination of N-methylformamide following occupational exposure to N,N-dimethylformamide
Original title Il dosaggio della N-metilformamide nella esposizione professionale a N,N-dimetilformamide [in Italian]
Bibliographic information Mar.-Apr. 2000, Vol.91, No.2, p.114-124. Illus. 29 ref.
Abstract To evaluate the correlation between the excretion of N-methylformamide (NMF) and levels of exposure to N,N-dimethylformamide (DMF) among occupationally exposed persons, 25 male workers aged between 25 and 54 in a synthetic leather factory were studied daily over a 5-day period. The mean time-weighted average (TWA) exposure was about half (13.5mg/m3) of the current threshold limit value, the range of the values varying from 0.4 to 75.2mg/m3. A linear equation existed between urinary NMF concentration and DMF concentration in the environment. The findings show that the urinary NMF concentration can be used as an appropriate biological exposure index. For occupationally exposed subjects, a urinary NMF concentration corresponding to the time-weighted average of the threshold limit value of 39.9mg/L (37.2mg/g creatinine) and a 95% lower confidence limit (biological threshold) of 23.4mg/L (22.2mg/g creatinine) are suggested.
Descriptors (primary) methylformamide; exposure tests; plastics converting industry; dimethylformamide
Descriptors (secondary) threshold limit values; creatinine; determination in urine; exposure evaluation; urinary excretion
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Amides
Biological monitoring