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CISDOC database

Document ID (ISN)76639
CIS number 01-837
ISSN - Serial title 0091-7370 - Annals of Clinical and Laboratory Science
Year 2001
Convention or series no.
Author(s) Sunderman F.W.
Title Nasal toxicity, carcinogenicity, and olfactory uptake of metals
Bibliographic information 2001, Vol.31, No.1, p.3-24. 169 ref.
Abstract This review article discusses the impact of occupational exposures to metal dusts or aerosols, which can cause loss of olfactory acuity, atrophy of the nasal mucosa, mucosal ulcers, perforated nasal septum and sinonasal cancer. Anosmia and hyposmia have been observed in workers exposed to nickel- or cadmium-containing dusts in alkaline battery factories, nickel refineries, and cadmium industries. Ulcers of the nasal mucosa and perforated nasal septum have been reported in workers exposed to Cr(VI) in chromate production and chrome plating, or to As(III) in arsenic smelters. Cancers of the nose and nasal sinuses have been reported in workers exposed to Ni compounds in nickel refining, cutlery factories, and alkaline battery manufacture, or to Cr(VI) in chromate production and chrome plating. Possible molecular mechanisms responsible for olfactory loss are proposed, based on the findings of several animal experiments.
Descriptors (primary) perforation of the nasal septum; nasal cancer; inhalation; ulceration of the nasal mucosa; aerosols; metal fumes; loss of smell; dust
Descriptors (secondary) literature survey; cadmium and compounds; nickel and compounds; arsenic and compounds; smelting plants; animal experiments; hardware industry; battery and dry cell manufacture; electroplating
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Metal production and metalworking
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of other sense organs (other than the eye and the ears)
Diseases of the respiratory system (except for pneumoconiosis & similar)