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CISDOC database

Document ID (ISN)76628
CIS number 01-832
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2001
Convention or series no.
Author(s) Lee P.N.
Title Relation between exposure to asbestos and smoking jointly and the risk of lung cancer
Bibliographic information Mar. 2001, Vol.58, No.3, p.145-153. 37 ref.
Abstract To review evidence of the relationship between the combined effect of exposure to asbestos and smoking on the risk of lung cancer, 23 studies epidemiological studies were analysed, comparing the risk of lung cancer in subjects unexposed to asbestos or smoking, exposed to asbestos only, to smoking only, or to both. Eight studies provided insufficient data. Asbestos exposure was associated with a significantly increased risk in non-smokers in six of the remaining studies and with a moderate increase in a further six. In two of the three studies that found no increase, asbestos exposure was insufficient to increase risks in smokers. In 30 of 31 data sets analysed, risk in the combined exposure group was greater than predicted by the additive model. Asbestos exposure multiplies risk of lung cancer by a similar factor in non-smokers and smokers.
Descriptors (primary) asbestos; hazard evaluation; lung cancer; smoking
Descriptors (secondary) literature survey
Document type D - Periodical articles
Country / State or ProvinceUnited Kingdom
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Risk evaluation