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Document ID (ISN)76621
CIS number 01-831
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2000
Convention or series no.
Author(s) Larkin E.K., Smith T.J., Stayner L., Rosner B., Speizer F.E., Garshick E.
Title Diesel exhaust exposure and lung cancer: Adjustment for the effect of smoking in a retrospective cohort study
Bibliographic information Oct. 2000, Vol.38, No.4, p.399-409. 33 ref.
Abstract The extent that cigarette smoking may confound the relationship between diesel exhaust exposure and lung cancer was assessed in a retrospective cohort study of 55,395 U.S. railroad workers followed from 1959 to 1976. The relative risk (RR) of lung cancer due to diesel exhaust was indirectly adjusted using job-specific smoking data from a case-control study of railroad workers who died between 1981-1982 and from a survey of 514 workers who had responded to a mail survey in 1982. Adjustment factors were developed based on the distribution of job-specific smoking rates. The unadjusted RR for lung cancer was 1.58 for workers aged 40-44 in 1959, who experienced the longest possible duration of exposure, and the smoking adjusted RR was 1.44. After considering differences in smoking rates between workers exposed and unexposed to diesel exhaust in a relatively large blue-collar cohort, there were still elevated risks of lung cancer in workers in jobs with diesel exhaust exposure.
Descriptors (primary) diesel engines; rail transport; lung cancer; smoking
Descriptors (secondary) hazard evaluation; blue-collar workers; cohort study; confounding factors
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Rail transportation
Smoking