|Document ID (ISN)||76621|
|ISSN - Serial title
||0271-3586 - American Journal of Industrial Medicine
|Convention or series no.
||Larkin E.K., Smith T.J., Stayner L., Rosner B., Speizer F.E., Garshick E.
||Diesel exhaust exposure and lung cancer: Adjustment for the effect of smoking in a retrospective cohort study
||Oct. 2000, Vol.38, No.4, p.399-409. 33 ref.
||The extent that cigarette smoking may confound the relationship between diesel exhaust exposure and lung cancer was assessed in a retrospective cohort study of 55,395 U.S. railroad workers followed from 1959 to 1976. The relative risk (RR) of lung cancer due to diesel exhaust was indirectly adjusted using job-specific smoking data from a case-control study of railroad workers who died between 1981-1982 and from a survey of 514 workers who had responded to a mail survey in 1982. Adjustment factors were developed based on the distribution of job-specific smoking rates. The unadjusted RR for lung cancer was 1.58 for workers aged 40-44 in 1959, who experienced the longest possible duration of exposure, and the smoking adjusted RR was 1.44. After considering differences in smoking rates between workers exposed and unexposed to diesel exhaust in a relatively large blue-collar cohort, there were still elevated risks of lung cancer in workers in jobs with diesel exhaust exposure.
||diesel engines; rail transport; lung cancer; smoking
||hazard evaluation; blue-collar workers; cohort study; confounding factors
||D - Periodical articles
|Country / State or Province||USA|
|Broad subject area(s)
||Diseases of the respiratory system (except for pneumoconiosis & similar)