|Document ID (ISN)||76604|
|ISSN - Serial title
||0003-4878 - Annals of Occupational Hygiene
|Convention or series no.
||Roggli V.L., Sanders L.L.
||Asbestos content of lung tissue and carcinoma of the lung: A clinicopathologic correlation and mineral fiber analysis of 234 cases
||Mar. 2000, Vol.44, No.2, p.109-117. 35 ref.
||The aim of this study was to investigate the asbestos content of lung tissue in patients with lung cancer and asbestos exposure. This information was then correlated with demographic information, occupational and smoking history, presence or absence of pathologic asbestosis or pleural plaques, and features of lung cancer. Asbestos body counts were performed in 229 cases and fibre analysis by scanning electron microscopy in 221 cases. Asbestos content was recorded as total asbestos fibres, commercial amphibole fibres, noncommercial amphibole fibres and chrysotile fibres 5Ám or longer in length. The study group included 70 patients with asbestosis (group I), 44 patients with parietal pleural plaques (group II) and 120 patients with neither (group III). The median asbestos body content of group I was more than 35 times greater than group II and more than 300 times greater than group III. The total asbestos fibre count for group I was nearly 20 times that of group II and more than 50 times that of group III. In a series of primary lung cancer cases with some history of asbestos exposure, a markedly elevated asbestos content was identified among those with pathologic asbestosis as compared with patents with pleural plaques alone or with neither plaques nor asbestosis.
||asbestos; mineral fibres; lung cancer; lung deposition
||fibre counts; pleural thickening; case study; pathogenesis; asbestos bodies; scanning electron microscopy; asbestosis
||D - Periodical articles
|Country / State or Province||USA|
||Dust, aerosols and related diseases
|Broad subject area(s)
Diseases of the respiratory system (except for pneumoconiosis & similar)