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Document ID (ISN)76604
CIS number 01-818
ISSN - Serial title 0003-4878 - Annals of Occupational Hygiene
Year 2000
Convention or series no.
Author(s) Roggli V.L., Sanders L.L.
Title Asbestos content of lung tissue and carcinoma of the lung: A clinicopathologic correlation and mineral fiber analysis of 234 cases
Bibliographic information Mar. 2000, Vol.44, No.2, p.109-117. 35 ref.
Abstract The aim of this study was to investigate the asbestos content of lung tissue in patients with lung cancer and asbestos exposure. This information was then correlated with demographic information, occupational and smoking history, presence or absence of pathologic asbestosis or pleural plaques, and features of lung cancer. Asbestos body counts were performed in 229 cases and fibre analysis by scanning electron microscopy in 221 cases. Asbestos content was recorded as total asbestos fibres, commercial amphibole fibres, noncommercial amphibole fibres and chrysotile fibres 5Ám or longer in length. The study group included 70 patients with asbestosis (group I), 44 patients with parietal pleural plaques (group II) and 120 patients with neither (group III). The median asbestos body content of group I was more than 35 times greater than group II and more than 300 times greater than group III. The total asbestos fibre count for group I was nearly 20 times that of group II and more than 50 times that of group III. In a series of primary lung cancer cases with some history of asbestos exposure, a markedly elevated asbestos content was identified among those with pathologic asbestosis as compared with patents with pleural plaques alone or with neither plaques nor asbestosis.
Descriptors (primary) asbestos; mineral fibres; lung cancer; lung deposition
Descriptors (secondary) fibre counts; pleural thickening; case study; pathogenesis; asbestos bodies; scanning electron microscopy; asbestosis
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Dust, aerosols and related diseases
Broad subject area(s) Chemical safety
Browse category(ies) Asbestos
Diseases of the respiratory system (except for pneumoconiosis & similar)