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Document ID (ISN)76597
CIS number 01-830
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2001
Convention or series no.
Author(s) Sanderson W.T., Ward E.M., Steenland K., Petersen M.R.
Title Lung cancer case-control study of beryllium workers
Bibliographic information Feb. 2001, Vol.39, No.2, p.133-144. 37 ref.
Abstract This article describes a case-control study of lung cancer among workers of a beryllium processing plant in Reading, PA, USA. Cases were identified by mortality follow-up through 1992 of a cohort of male workers. Each of 142 cases was age-race-matched to five controls. The potential confounding effects of smoking were also evaluated. Lung cancer cases had shorter tenures and lower cumulative beryllium exposures than controls, but higher average and maximum exposures. However, after applying a 10- and 20-year lag, exposure metrics were higher for cases. Odds ratios in analyses that lagged 20 years were significantly elevated for those with higher exposure compared to the lowest exposure category. Significant positive trends were seen with the log of the exposure metrics. Increased lung cancer among workers with higher lagged beryllium exposures and lack of evidence for confounding by cigarette smoking, provide further evidence that beryllium is a human lung carcinogen.
Descriptors (primary) beryllium; job-exposure relation; lung cancer; mortality
Descriptors (secondary) USA; Pennsylvania; smoking; length of service; statistical evaluation; case-control study; long-term study; long-term exposure; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances
Diseases of the respiratory system (except for pneumoconiosis & similar)