|Document ID (ISN)||76597|
|ISSN - Serial title
||0271-3586 - American Journal of Industrial Medicine
|Convention or series no.
||Sanderson W.T., Ward E.M., Steenland K., Petersen M.R.
||Lung cancer case-control study of beryllium workers
||Feb. 2001, Vol.39, No.2, p.133-144. 37 ref.
||This article describes a case-control study of lung cancer among workers of a beryllium processing plant in Reading, PA, USA. Cases were identified by mortality follow-up through 1992 of a cohort of male workers. Each of 142 cases was age-race-matched to five controls. The potential confounding effects of smoking were also evaluated. Lung cancer cases had shorter tenures and lower cumulative beryllium exposures than controls, but higher average and maximum exposures. However, after applying a 10- and 20-year lag, exposure metrics were higher for cases. Odds ratios in analyses that lagged 20 years were significantly elevated for those with higher exposure compared to the lowest exposure category. Significant positive trends were seen with the log of the exposure metrics. Increased lung cancer among workers with higher lagged beryllium exposures and lack of evidence for confounding by cigarette smoking, provide further evidence that beryllium is a human lung carcinogen.
||beryllium; job-exposure relation; lung cancer; mortality
||USA; Pennsylvania; smoking; length of service; statistical evaluation; case-control study; long-term study; long-term exposure; exposure evaluation
||D - Periodical articles
|Country / State or Province||USA|
|Broad subject area(s)
Diseases of the respiratory system (except for pneumoconiosis & similar)