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CISDOC database

Document ID (ISN)76595
CIS number 01-835
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2001
Convention or series no.
Author(s) Ji B.T., Silverman D.T., Stewart P.A., Blair A., Swanson G.M., Baris D., Greenberg R.S., Hayes R.B., Brown L.M., Lillemoe K.D., Schoenberg J.B., Pottern L.M., Schwartz A.G., Hoover R.N.
Title Occupational exposure to pesticides and pancreatic cancer
Bibliographic information Jan. 2001, Vol.39, No.1, p.92-99. 45 ref.
Abstract To investigate the relationship between pancreatic cancer and exposure to pesticides, a case-control study was conducted in three separate areas of the United States, involving 484 cases aged 30-79 diagnosed in 1986-1989 and 2,095 controls drawn from a random sample of the general population. A job-exposure matrix (JEM) approach was used to estimate the level of occupational exposure to pesticides. A significant trend in risk with increasing exposure level of pesticides was observed, with odds ratios (OR) of 1.3 and 1.4 for low and moderate-high exposure levels, respectively. Excess risks were found for occupational exposure to fungicides (OR = 1.5) and herbicides (OR = 1.6) in the moderate-high level after adjustment for potential confounding factors. An increased risk for insecticide exposure was no longer significant after adjustment for fungicide and herbicide exposures. Results suggest that pesticides may increase the risk of pancreatic cancer, and highlight the need for further research to evaluate the risk of exposure to specific chemicals.
Descriptors (primary) pesticides; tumour of the pancreas; agriculture; hazard evaluation; cancer
Descriptors (secondary) USA; exposure evaluation; statistical evaluation; job-exposure relation; case-control study
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s) Chemical safety
Browse category(ies) Endocrine diseases
Agriculture
Agricultural chemicals
Risk evaluation