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Document ID (ISN)76524
CIS number 01-491
ISSN - Serial title 1575-1392 - Prevenciˇn, trabajo y salud
Year 2000
Convention or series no.
Author(s) de la Iglesia Huerta A., Delgado Cobos P.
Title Pesticides: Neurotoxicity and heath surveillance
Original title Plaguicidas: Neurotoxicidad y vigilancia de la salud [in Spanish]
Bibliographic information 2000, No.8, p.4-14. Illus. 50 ref.
Abstract Spain is the fifth largest consumer of crop protection products in Europe, of which 80% are organophosphorus compounds. The aetiology and pathogenesis of this class of compounds is described. The most important mode of poisoning is through skin absorption, while ingestion is mainly by accident or a result of poor hygiene, and inhalation risk is a function of the products' volatility. The immediate effects of poisoning are muscarinic and nicotinic effects, as well as neurological effects. Neurotoxic effects may be delayed, and can appear several days or weeks after the poisoning. For this reason, regular medical checks and biological monitoring are necessary, in particular the determination of plasmatic acetylcholinesterase and cholinesterase, and the detection of possible urinary metabolites, in order to evaluate exposure. Use of the Peradeniya scale, which assigns ratings to five organophosphorus poisoning symptoms, enables the determination of the severity of the poisoning.
Descriptors (primary) neurotoxic effects; medical supervision; pesticides; pesticide poisoning
Descriptors (secondary) cholinesterase monitoring; Spain; organophosphorus compounds; exposure evaluation; skin absorption; diagnosis; cholinesterase
Document type D - Periodical articles
Country / State or ProvinceSpain
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the nervous system
Agricultural chemicals