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Document ID (ISN)76444
CIS number 01-507
ISBN(s) 3-89701-366-5
Year 1999
Convention or series no. Fb 848
Author(s) Bellmann B., Muhle H.
Bundesanstalt für Arbeitsschutz und Arbeitsmedizin
Title Investigation of the in vivo solubility of fibrous vitreous silica dust samples
Original title Untersuchung der in-vivo-Löslichkeit von glasigen silicatischen Faserstäuben [in German]
Bibliographic information Wirtschaftsverlag NW, Postfach 10 11 10, 27511 Bremerhaven, Germany, 1999. vii, 65p. Illus. 16 ref.
Abstract This research report examines the elimination of mineral fibres from the lungs of rats and the transposition of the results to man. Such fibres disappear either by chemical dissolution or through a macrophage-mediated lung-clearance process, the latter being however much slower in man than in the rat. The objective of this study was to establish whether by slowing down of the lung-clearance process through additional instillation of poorly soluble plastic (such as toner powder), one could alter the mineral fibre dissolution process. The elimination of ceramic fibres was delayed by the addition of plastic particles, while the elimination of rock fibres was not modified. It was observed that in the presence of plastic particles, glass fibres were eliminated more rapidly. This could be due to a slowing down of fibre phagocytosis by macrophages, which could favour a more rapid dissolution of the fibres, the pH inside the macrophages being less acidic. The application of this experimental model will enable a better understanding of the kinetics of lung elimination of different types of mineral fibres. Summaries in English and French.
Descriptors (primary) inorganic man-made fibres; lung diseases; silicates
Descriptors (secondary) glass fibre; alveolar clearance; extrapolation animal man; animal experiments; ceramic fibres
Document type E - Books, reports, proceedings
Country / State or ProvinceGermany
Subject(s) Dust, aerosols and related diseases
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Silicon compounds
Inorganic substances