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Document ID (ISN)76381
CIS number 01-510
Year 1997
Convention or series no. CE-V/4-97-007-EN-C
Author(s) FoÓ V.
5th ECSC Medical research programme
Title Biological indicators of exposure, internal dose, biological effective dose and of early biological effects in coke oven workers exposed to genotoxic compound (PAH)
Bibliographic information European Commission, Directorate-General V, Employment, Industrial Relations and Social Affairs Directorate V/F, Public Health and Safety at Work Unit V/F/5 Occupational Health and Hygiene, EUROFORUM Building, 2920 Luxembourg, Grand Duchy of Luxembourg, 1997. 115p. Illus. Bibl.ref.
Abstract This study compares a high-risk group of coke-oven workers exposed do PAH with a reference group in order to evaluate the levels of environmental exposure and the biomarkers of internal dose (urinary 1-hydroxyphenol and urinary mutagenicity), of effective dose (DNA and haemoglobin adducts) and of early genomic modifications. Levels of DNA adducts, amino-haemoglobin adducts and sister chromatid exchanges were significantly higher in coke workers and depending on their job, certain categories of workers showed a higher risk. Urinary hypoxypyrene was associated with a high level of DNA adducts; urinary mutagenicity was associated with the amino-fluoranthrene haemoglobin adducts. Smoking was associated with both PAH-DNA and amino-haemoglobin adducts. Summaries in French, German and Italian.
Descriptors (primary) aromatic hydrocarbons; exposure tests; genetic effects; polycyclic hydrocarbons
Descriptors (secondary) European Communities; smoking; determination in urine; chromosome changes; determination in blood; case-control study
Document type E - Books, reports, proceedings
Country / State or ProvinceEuropean Union; Italy
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Biological monitoring
Polycyclic hydrocarbons
Aromatic hydrocarbons
Genetic factors in reaction to exposures