|Document ID (ISN)||76381|
|Convention or series no.
5th ECSC Medical research programme
||Biological indicators of exposure, internal dose, biological effective dose and of early biological effects in coke oven workers exposed to genotoxic compound (PAH)
||European Commission, Directorate-General V, Employment, Industrial Relations and Social Affairs Directorate V/F, Public Health and Safety at Work Unit V/F/5 Occupational Health and Hygiene, EUROFORUM Building, 2920 Luxembourg, Grand Duchy of Luxembourg, 1997. 115p. Illus. Bibl.ref.
||This study compares a high-risk group of coke-oven workers exposed do PAH with a reference group in order to evaluate the levels of environmental exposure and the biomarkers of internal dose (urinary 1-hydroxyphenol and urinary mutagenicity), of effective dose (DNA and haemoglobin adducts) and of early genomic modifications. Levels of DNA adducts, amino-haemoglobin adducts and sister chromatid exchanges were significantly higher in coke workers and depending on their job, certain categories of workers showed a higher risk. Urinary hypoxypyrene was associated with a high level of DNA adducts; urinary mutagenicity was associated with the amino-fluoranthrene haemoglobin adducts. Smoking was associated with both PAH-DNA and amino-haemoglobin adducts. Summaries in French, German and Italian.
||aromatic hydrocarbons; exposure tests; genetic effects; polycyclic hydrocarbons
||European Communities; smoking; determination in urine; chromosome changes; determination in blood; case-control study
||E - Books, reports, proceedings
|Country / State or Province||European Union; Italy|
||Toxic and dangerous substances
|Broad subject area(s)
||Antifertility and prenatal effects
Genetic factors in reaction to exposures