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Document ID (ISN)76344
CIS number 01-487
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 1996
Convention or series no.
Author(s) Lind P., Dalene M., Skarping G., Hagmar L.
Title Toxicokinetics of 2,4- and 2,6-toluenediamine in hydrolysed urine and plasma after occupational exposure to 2,4- and 2,6-toluene diisocyanate
Bibliographic information Feb. 1996, Vol.53, No.2, p.94-99. Illus. 16 ref.
Abstract To assess the toxicokinetics of 2,4- and 2,6- toluene diisocyanate (TDI) in chronically exposed subjects, blood and urine from 11 Swedish workers at two flexible foam polyurethane production plants were sampled. Using gas chromatography-mass spectrometry (GC-MS) 2,4- and 2,6-toluene diamine (TDA) were measured as pentafluoropropionic anhydride derivatives after acidic hydrolysis of plasma (P-TDA, ng/mL) and urine (U-TDA, µg/h). Concentrations of P-2,4-TDA and P-2,6-TDA, and urinary elimination rates of 2,4-TDA and 2,6-TDA before and after holiday periods are reported for each of the plants. The half-life in plasma of chronically exposed workers for 2,4- and 2,6-TDA was twice as long as for volunteers with short term exposure. An indication of a two-phase elimination pattern in urine was found. The first phase was related to the more recent exposure and the much slower second phase was probably related to release of TDA in urine from TDI adducts in the body.
Descriptors (primary) metabolic process; 2,4-diaminotoluene; 2,6-diaminotoluene; 2,4-tolylene diisocyanate; 2,6-tolylene diisocyanate
Descriptors (secondary) foams; polyurethanes; Sweden; determination in urine; long-term exposure; determination in blood; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Aromatic amines
Cyano compounds