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Document ID (ISN)76329
CIS number 01-497
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2000
Convention or series no.
Author(s) Jang A.S., Choi I.S., Koh Y.I., Moon J.D., Lee K.J.
Title Increase in airway hyperresponsiveness among workers exposed to methylene diphenyldiisocyanate compared to workers exposed to toluene diisocyanate at a petrochemical plant in Korea
Bibliographic information June 2000, Vol.37, No.6, p.663-667. Illus. 29 ref.
Abstract To investigate airway hyperresponsiveness induced by methylene diphenyldiisocyanate (MDI) and toluene diisocyanate (TDI), questionnaires, allergic skin test results and nonspecific airway hyperresponsiveness (AHR) test results were studied in 64 exposed workers and 27 controls at a petrochemical complex in the Republic of Korea. Methacholine challenge tests were done, and the Bronchial Responsiveness Index (BRindex) calculated. Prevalence of AHR was higher in MDI-exposed workers than in TDI-exposed workers (20% vs. 4.7%). 23 workers of all subjects had respiratory symptoms. MDI-exposed workers had higher BRindex (0.73 vs. 0.62 for controls). Workers exposed to TDI or MDI with respiratory symptoms, in comparison with exposed workers without respiratory symptoms, had a significantly higher BRindex (0.82 vs. 0.60). There was a significant negative correlation between FEV1 and Brindex. Workers exposed to MDI are at a higher risk of asthma in comparison with TDI-exposed workers and control subjects.
Descriptors (primary) diphenylmethane diisocyanate; respiratory impairment; tolylene diisocyanate
Descriptors (secondary) Korea, Republic of; methacholine; comparative study; one-second forced expiratory volume; inhalation tests; allergic asthma
Document type D - Periodical articles
Country / State or ProvinceKorea, Republic of
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Isocyanates
Cyano compounds