| Document ID (ISN) | 76329 |
| CIS number |
01-497 |
| ISSN - Serial title |
0271-3586 - American Journal of Industrial Medicine |
| Year |
2000 |
| Convention or series no. |
|
| Author(s) |
Jang A.S., Choi I.S., Koh Y.I., Moon J.D., Lee K.J. |
| Title |
Increase in airway hyperresponsiveness among workers exposed to methylene diphenyldiisocyanate compared to workers exposed to toluene diisocyanate at a petrochemical plant in Korea |
| Bibliographic information |
June 2000, Vol.37, No.6, p.663-667. Illus. 29 ref. |
| Abstract |
To investigate airway hyperresponsiveness induced by methylene diphenyldiisocyanate (MDI) and toluene diisocyanate (TDI), questionnaires, allergic skin test results and nonspecific airway hyperresponsiveness (AHR) test results were studied in 64 exposed workers and 27 controls at a petrochemical complex in the Republic of Korea. Methacholine challenge tests were done, and the Bronchial Responsiveness Index (BRindex) calculated. Prevalence of AHR was higher in MDI-exposed workers than in TDI-exposed workers (20% vs. 4.7%). 23 workers of all subjects had respiratory symptoms. MDI-exposed workers had higher BRindex (0.73 vs. 0.62 for controls). Workers exposed to TDI or MDI with respiratory symptoms, in comparison with exposed workers without respiratory symptoms, had a significantly higher BRindex (0.82 vs. 0.60). There was a significant negative correlation between FEV1 and Brindex. Workers exposed to MDI are at a higher risk of asthma in comparison with TDI-exposed workers and control subjects. |
| Descriptors (primary) |
diphenylmethane diisocyanate; respiratory impairment; tolylene diisocyanate |
| Descriptors (secondary) |
Korea, Republic of; methacholine; comparative study; one-second forced expiratory volume; inhalation tests; allergic asthma |
| Document type |
D - Periodical articles |
| Country / State or Province | Korea, Republic of |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Cyano compounds
Diseases of the respiratory system (except for pneumoconiosis & similar)
Isocyanates
|
