|Document ID (ISN)||76322|
|ISSN - Serial title
||0271-3586 - American Journal of Industrial Medicine
|Convention or series no.
||Hydrocarbons may worsen renal function in glomerulonephritis: A meta-analysis of the case-control studies
||June 2000, Vol.37, No.6, p.599-606. Illus. 38 ref.
||The association between stage of glomerulonephritis and degree of previous hydrocarbon exposure was studied by a meta-analysis of all published case-control studies and by reviewing all follow-up studies. Odds ratios (OR) for exposure could be calculated for 16 patient groups from 14 case-control studies. After exclusion of four patient groups with 5-17% drop-outs due to death, the mean weighted OR for patient groups with acute or early glomerulonephritis, chronic renal failure and end-stage renal failure were 0.95, 3.1 and 5.9, respectively. At follow-up, reported in four studies, renal failure was mainly seen in patients with extensive exposure, and improvement was seen only in patients who had discontinued the exposure. In conclusion, hydrocarbon exposure in glomerulonephritis is associated with the advancement of the disease and inversely associated with renal function. Early elimination of the exposure may, therefore, prevent the progress of renal failure in many patients.
||hydrocarbons; renal insufficiency; nephritis
||literature survey; length of exposure; case-control study; renal dysfunction
||D - Periodical articles
|Country / State or Province||Sweden|
|Broad subject area(s)
||Diseases of the kidney and the urinary system