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CISDOC database

Document ID (ISN)76322
CIS number 01-496
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2000
Convention or series no.
Author(s) Ravnskov U.
Title Hydrocarbons may worsen renal function in glomerulonephritis: A meta-analysis of the case-control studies
Bibliographic information June 2000, Vol.37, No.6, p.599-606. Illus. 38 ref.
Abstract The association between stage of glomerulonephritis and degree of previous hydrocarbon exposure was studied by a meta-analysis of all published case-control studies and by reviewing all follow-up studies. Odds ratios (OR) for exposure could be calculated for 16 patient groups from 14 case-control studies. After exclusion of four patient groups with 5-17% drop-outs due to death, the mean weighted OR for patient groups with acute or early glomerulonephritis, chronic renal failure and end-stage renal failure were 0.95, 3.1 and 5.9, respectively. At follow-up, reported in four studies, renal failure was mainly seen in patients with extensive exposure, and improvement was seen only in patients who had discontinued the exposure. In conclusion, hydrocarbon exposure in glomerulonephritis is associated with the advancement of the disease and inversely associated with renal function. Early elimination of the exposure may, therefore, prevent the progress of renal failure in many patients.
Descriptors (primary) hydrocarbons; renal insufficiency; nephritis
Descriptors (secondary) literature survey; length of exposure; case-control study; renal dysfunction
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the kidney and the urinary system