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Document ID (ISN)76038
CIS number 01-134
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 1999
Convention or series no.
Author(s) Apostoli P., Bartoli D., Alessio L., Buchet J.P.
Title Biological monitoring of occupational exposure to inorganic arsenic
Bibliographic information Dec. 1999, Vol.56, No.12, p.825-832. Illus. 66 ref.
Abstract The study was undertaken to assess biological indicators for monitoring occupational exposure to inorganic arsenic (iAs), taking into account the possible confounding role of arsenicals present in food and drinking water. 51 glass workers exposed to arsenic (As) trioxide, a control group of 39 subjects not exposed and eight volunteers who drank water containing 45µg/L iAs for a week were monitored for total arsenic in air and urine samples, and for urinary As3, As5, monomethyl arsonic acid, dimethyl arsinic acid, and arsenobetaine. The best correlations between As in air and its urinary species were found for total iAs and As3+As5. It is proposed that urinary As3+As5 be used as an indicator for monitoring the exposure to iAs. For the current environmental limit for iAs of 10µg/m3, the limit for urinary As3+As5 was calculated to be around 5µg/L. Trivalent arsenic is the most active species and its measured concentration in urine could be the best predictor of some critical effects of the element, such as cancer.
Descriptors (primary) workplace monitoring; urine monitoring; exposure tests; arsenic and compounds
Descriptors (secondary) cancer; limitation of exposure; permissible levels; exposure evaluation; arsenic trioxide; glass industry; determination in air; determination in urine; methylarsonic acid; drinking water
Document type D - Periodical articles
Country / State or ProvinceBelgium; Italy
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Arsenic and compounds
Inorganic substances