|Document ID (ISN)||76016|
|ISSN - Serial title
||0376-7639 - Médecine du travail & Ergonomie / Arbeidsgezondheitszorg & Ergonomie
|Convention or series no.
||Vancraeynest D., Lardot C., Huaux F., Lison D.
||Evaluation of nasal lavage as a possible tool in occupational medicine for the diagnosis of inflammatory diseases of the respiratory system
||Evaluation du lavage nasal comme outil possible pour le dépistage de pathologies inflammatoires du système respiratoire en médecine du travail [in French]|
||1998, Vol.35, No.4, p.169-182. Illus. 42 ref.
||Occupational exposure to laboratory animals can cause an inflammatory reaction of the respiratory tract. The present study assessed the value of nasal lavage (NAL) to detect an early inflammatory reaction. NAL was performed in 10 volunteers from a research laboratory; five of them had been repeatedly exposed to laboratory animals and five others had not. Except for one subject who did not participate in the last examination, all subjects were lavaged on four different occasions over a period of 3 months. Analysis of NAL fluid included cellular parameters and inflammatory mediators. Before each lavage the main factors that may have influenced nasal inflammation were recorded. Cellular parameters showed large inter- and intra-individual variability and were barely contributive. Inflammatory mediators were more influenced by smoking and upper airway diseases than by exposure to laboratory animals. The heterogeneity of the studied population, which is comparable to what is commonly encountered in occupational settings, together with the variability of inflammation of the upper respiratory tract render the interpretation of the results difficult. It is concluded that NAL cannot be recommended for the periodical examination of workers potentially exposed to irritants and/or sensitising agents.
||nose; upper respiratory diseases; determination in biological matter; handling of animals; inflammations
||irritants; interleukins; experimental animals; smoking; allergic respiratory disorders; human experiments; subject variability; description of technique; occupational medicine; diagnosis
||D - Periodical articles
|Country / State or Province||Belgium|
|Broad subject area(s)
||Occupational medicine, epidemiology
Diseases of the respiratory system (except for pneumoconiosis & similar)