ILO Home
Go to the home page
Site map | Contact us Français | Español

CISDOC database

Document ID (ISN)76016
CIS number 01-108
ISSN - Serial title 0376-7639 - Médecine du travail & Ergonomie / Arbeidsgezondheitszorg & Ergonomie
Year 1998
Convention or series no.
Author(s) Vancraeynest D., Lardot C., Huaux F., Lison D.
Title Evaluation of nasal lavage as a possible tool in occupational medicine for the diagnosis of inflammatory diseases of the respiratory system
Original title Evaluation du lavage nasal comme outil possible pour le dépistage de pathologies inflammatoires du système respiratoire en médecine du travail [in French]
Bibliographic information 1998, Vol.35, No.4, p.169-182. Illus. 42 ref.
Abstract Occupational exposure to laboratory animals can cause an inflammatory reaction of the respiratory tract. The present study assessed the value of nasal lavage (NAL) to detect an early inflammatory reaction. NAL was performed in 10 volunteers from a research laboratory; five of them had been repeatedly exposed to laboratory animals and five others had not. Except for one subject who did not participate in the last examination, all subjects were lavaged on four different occasions over a period of 3 months. Analysis of NAL fluid included cellular parameters and inflammatory mediators. Before each lavage the main factors that may have influenced nasal inflammation were recorded. Cellular parameters showed large inter- and intra-individual variability and were barely contributive. Inflammatory mediators were more influenced by smoking and upper airway diseases than by exposure to laboratory animals. The heterogeneity of the studied population, which is comparable to what is commonly encountered in occupational settings, together with the variability of inflammation of the upper respiratory tract render the interpretation of the results difficult. It is concluded that NAL cannot be recommended for the periodical examination of workers potentially exposed to irritants and/or sensitising agents.
Descriptors (primary) nose; upper respiratory diseases; determination in biological matter; handling of animals; inflammations
Descriptors (secondary) irritants; interleukins; experimental animals; smoking; allergic respiratory disorders; human experiments; subject variability; description of technique; occupational medicine; diagnosis
Document type D - Periodical articles
Country / State or ProvinceBelgium
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Livestock rearing
Diseases of the respiratory system (except for pneumoconiosis & similar)