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Document ID (ISN)75993
CIS number 01-151
ISSN - Serial title 0105-1873 - Contact Dermatitis
Year 2000
Convention or series no.
Author(s) Boman A., Montelius J., Rissanen R.L., LidÚn C.
Title Sensitizing potential of chlorothalonil in the guinea pig and the mouse
Bibliographic information Nov. 2000, Vol.43, No.5, p.273-279. Illus. 35 ref.
Abstract Chlorothalonil is extensively used for the protection of horticultural and fruit crops against fungal infections. It is also used in wood preservation and as a preservative in paints. Clinical experience has shown chlorothalonil to be a contact allergen and several cases of allergic contact dermatitis attributed to chlorothalonil have been described. Two previous guinea pig maximization test studies have shown the sensitizing potential of chlorothalonil to be high. The sensitizing property of chlorothalonil was studied with the predictive test methods, the local lymph node assay and the cumulative contact enhancement test. In the local lymph node assay, chlorothalonil induced a dose-dependent increase in proliferation with a maximal stimulation index of 19.2 and 27.2. In the cumulative contact enhancement test, a dose-dependent high sensitization rate was seen with a maximal sensitization rate of 100%. In conclusion, chlorothalonil is an extremely potent contact allergen, inducing sensitization simply from topical exposure on intact skin.
Descriptors (primary) allergens; sensitization; fungicides; 2,4,5,6-tetrachloroisophthalonitrile
Descriptors (secondary) lymph nodes; eczema; dose-response relationship; skin tests; animal experiments
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Cyano compounds
Agricultural chemicals