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Document ID (ISN)75736
CIS number 00-1604
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 1998
Convention or series no.
Author(s) Gustavsson P., Jakobsson R., Johansson H., Lewin F., Norell S., Rutkvist L.E.
Title Occupational exposures and squamous cell carcinoma of the oral cavity, pharynx, larynx, and oesophagus: A case-control study in Sweden
Bibliographic information June 1998, Vol.55, No.6, p.393-400. 27 ref.
Abstract This community-based case-referent study was initiated to investigate aetiological factors for squamous cell carcinoma of the upper gastrointestinal tract. The study was based on all Swedish men aged 40-79 living in two regions of Sweden during 1988-90. Exposure to asbestos was associated with an increased risk of laryngeal cancer, and a dose-response relation was present. The RR was 1.8 in the highest exposure group. More than eight years of exposure to welding fumes was associated with an increased risk of pharyngeal cancer (RR=2.3 (1.1 to 4.7)), and laryngeal cancer (RR=2.0). There were indications of a dose-response for duration of exposure. Associations were also found for high exposure to polycyclic aromatic hydrocarbons (PAHs) and oesophageal cancer (RR=1.9). Exposure to wood dust was associated with a decreased risk of cancer at the studied sites. The study indicates that welding may cause an increased risk of pharyngeal as well as laryngeal cancer. The findings corroborate an association between exposure to PAHs and oesophageal cancer.
Descriptors (primary) oesophageal carcinoma; laryngeal cancer; exposure; oral cancer; pharyngeal cancer
Descriptors (secondary) formaldehyde; wood dust; Sweden; aromatic hydrocarbons; asbestos; dose-response relationship; respirable dust; welding fumes; polycyclic hydrocarbons; case-control study; aetiology
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Mouth and teeth diseases
Diseases of the respiratory system (except for pneumoconiosis & similar)
Gastrointestinal diseases