|Document ID (ISN)||75557|
|Convention or series no.
||HSE Guidance Note EH 72/13
Health and Safety Executive
||Methyl cyanoacrylate and ethyl cyanoacrylate - Risk assessment document
||HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 2WA, United Kingdom, 2000. iv, 68p. Illus. Bibl.ref. Price: GBP 10.00.
||Main conclusions of this risk assessment document: little information is available on the toxicokinetics of methyl cyanoacrylate and ethyl cyanoacrylate. Vapours and aerosols are irritant to the eyes and the respiratory tract. There is no clear evidence of occup skin sensitization and little evidence of occupational asthma although in a number of case reports asthma has been linked to exposure to methyl cyanoacrylate and ethyl cyanoacrylate. There are no studies on effects of repeated exposure of ethyl cyanoacrylate in humans; overall effects of methyl cyanoacrylate and ethyl cyanoacrylate are local irritant responses. Methyl cyanoacrylate is a mutagen in S. tiphimurium whereas ethyl cyanoacrylate gives negative results; both seem unlikely to express mutagenic properties in vivo. There are no data available on carcinogenic or reproductive effects. Both substances have an OES of 0.3ppm (15min reference period) in the United Kingdom. No 8h-TWA has been set.
||cyanoacrylates; United Kingdom; exposure tests; methyl cyanoacrylate; toxicology; ethyl 2-cyanoacrylate
||toxic effects; literature survey; threshold limit values; criteria document; skin absorption; exposure evaluation; irritants
||B - Chemical safety information sheets
|Country / State or Province||United Kingdom|
||Toxic and dangerous substances
|Broad subject area(s)