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CISDOC database

Document ID (ISN)75418
CIS number 00-1390
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 1998
Convention or series no.
Author(s) London L., Myers J.E.
Title Use of a crop and job specific exposure matrix for retrospective assessment of long term exposure in studies of chronic neurotoxic effects of agrichemicals
Bibliographic information Mar. 1998, Vol.55, No.3, p.194-201. Illus. 53 ref.
Abstract The long term exposure of farm workers based on a job exposure matrix (JEM) developed for use in a study of the neurotoxic effects of organophosphates was estimated and the repeatability and validity of the JEM was evaluated. A JEM was constructed with secondary data from industry and expert opinion of the estimate of agrichemical exposure within every possible job activity in the JEM to weight job days for exposure to organophosphates. Cumulative lifetime and average intensity exposure of organophosphate exposure were calculated for 163 pesticide applicators and 84 controls. Repeat questionnaires were given to 29 participants three months later to test repeatability of measurements. The ability of JEM based exposure to predict a known marker of organophosphate exposure was used to validate the JEM. Cumulative lifetime exposure as measured in kg organophosphate exposure, was significantly associated with erythrocyte cholinesterase concentrations, controlled for a range of confounders. Repeatability and average lifetime intensity of exposure was adequate.
Descriptors (primary) neurotoxic effects; exposure evaluation; crop protection; agricultural chemicals
Descriptors (secondary) organophosphorus compounds; cholinesterase; long-term exposure; confounding factors; cross-sectional study; questionnaire survey
Document type D - Periodical articles
Country / State or ProvinceSouth Africa
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the nervous system
Agricultural chemicals
Exposure evaluation