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CISDOC database

Document ID (ISN)75411
CIS number 00-1397
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 1998
Convention or series no.
Author(s) Kevekordes S., Gebel T.W., Hellwig M., Dames W., Dunkelberg H.
Title Human effect monitoring in cases of occupational exposure to antineoplastic drugs: A method comparison
Bibliographic information Mar. 1998, Vol.55, No.3, p.145-149. Illus. 30 ref.
Abstract The aim of the study was to investigate whether DNA damage increased in subjects possibly exposed to high amounts of antineoplastic agents. The level of genetic damage was determined in peripheral mononuclear blood cells with the sister chromatid exchange test, the alkaline elusion technique and the cytokinesis block micronucleus test. The supposed increased exposure of the study subjects was caused by a malfunction of a safety hood resulting in leakage of air during preparation of an infusion of an antineoplastic drug. Two months after a new safety hood was installed, the frequencies of micronuclei and sister chromatic exchanges of exposed nurses were still significantly increased when compared with a matched control group. In a second examination seven months later, the frequency of micronuclei had significantly decreased to control values. Moreover, the study subjects who smoked had significantly increased frequencies of micronuclei and sister chromatid exchanges.
Descriptors (primary) antineoplastic drugs; exposure tests; genetic effects; health care personnel
Descriptors (secondary) DNA; evaluation of technique; comparative study; analysis of chromosome aberrations; medical supervision
Document type D - Periodical articles
Country / State or ProvinceGermany
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Health care services
Genetic factors in reaction to exposures
Biological monitoring