|Document ID (ISN)||75411|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Kevekordes S., Gebel T.W., Hellwig M., Dames W., Dunkelberg H.
||Human effect monitoring in cases of occupational exposure to antineoplastic drugs: A method comparison
||Mar. 1998, Vol.55, No.3, p.145-149. Illus. 30 ref.
||The aim of the study was to investigate whether DNA damage increased in subjects possibly exposed to high amounts of antineoplastic agents. The level of genetic damage was determined in peripheral mononuclear blood cells with the sister chromatid exchange test, the alkaline elusion technique and the cytokinesis block micronucleus test. The supposed increased exposure of the study subjects was caused by a malfunction of a safety hood resulting in leakage of air during preparation of an infusion of an antineoplastic drug. Two months after a new safety hood was installed, the frequencies of micronuclei and sister chromatic exchanges of exposed nurses were still significantly increased when compared with a matched control group. In a second examination seven months later, the frequency of micronuclei had significantly decreased to control values. Moreover, the study subjects who smoked had significantly increased frequencies of micronuclei and sister chromatid exchanges.
||antineoplastic drugs; exposure tests; genetic effects; health care personnel
||DNA; evaluation of technique; comparative study; analysis of chromosome aberrations; medical supervision
||D - Periodical articles
|Country / State or Province||Germany|
|Broad subject area(s)
||Antifertility and prenatal effects
Health care services
Genetic factors in reaction to exposures