ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)75124
CIS number 00-1061
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 1999
Convention or series no.
Author(s) Doekes G., Kamminga N., Helwegen L., Heederik D.
Title Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger
Bibliographic information July 1999, Vol.56, No.7, p.454-459. Illus. 23 ref.
Abstract The aim of this study was to assess whether work-related respiratory symptoms among workers in a premix factory producing animal feed additives could be due to type I (mediated by immunoglobulin E (IgE)) allergic sensitization to phytase. Strongest IgE reactions were found in four exposed workers who reported work-related respiratory symptoms, particularly wheezing, and in one internal control who possibly had become sensitized because the structure of the factory building did not preclude airborne exposure in the offices and corridors of the plant. Phytase is a potentially important new occupational allergen causing specific IgE immune responses among exposed workers. Such IgE sensitization could probably be the cause of work-related asthmatic and other respiratory symptoms if no effective measures are taken to prevent airborne occupational exposure at sites where phytase is handled, particularly during addition of enzyme preparations to animal feed.
Descriptors (primary) allergens; phosphatases; sensitization; feed production; respiratory diseases
Descriptors (secondary) Aspergillus moulds; individual susceptibility; case-control study; immunoglobulins
Document type D - Periodical articles
Country / State or ProvinceNetherlands
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Food industry
Diseases of the respiratory system (except for pneumoconiosis & similar)