|Document ID (ISN)||75123|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Leng G., Lewalter J.
||Role of individual susceptibility in risk assessment of pesticides
||July 1999, Vol.56, No.7, p.449-453. Illus. 36 ref.
||This study presents criteria for assessing the individual pesticide burden of workers in the chemical industry. A group of 1003 workers exposed to methylparathion or ethylparathion (alkyl phosphates), propoxur (carbamate) or cyfluthrin (pyrethroid) was investigated. After exposure, plasma concentrations of the products or their metabolites, p-nitrophenol concentration in urine, and activities of cholinesterase and acetylcholinesterase were measured. At the same propoxur concentration, only workers with a low individual acetylcholinesterase activity reported symptoms. Workers who metabolized cyfluthrin rapidly reported fewer symptoms than workers with a lower rate of metabolism. This tendency was also evident in cases of mixed exposure (cyfluthrin and methylparathion). In the assessment of exposure to pesticides, susceptibility of the individual person has to be considered.
||chemical industry; individual susceptibility; hazard evaluation; pesticides
||parathion; acetylcholinesterase; metabolic process; determination in urine; arprocarb; exposure evaluation; determination in blood; cyfluthrin
||D - Periodical articles
|Country / State or Province||Germany|
||Toxic and dangerous substances
|Broad subject area(s)