ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)75123
CIS number 00-1050
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 1999
Convention or series no.
Author(s) Leng G., Lewalter J.
Title Role of individual susceptibility in risk assessment of pesticides
Bibliographic information July 1999, Vol.56, No.7, p.449-453. Illus. 36 ref.
Abstract This study presents criteria for assessing the individual pesticide burden of workers in the chemical industry. A group of 1003 workers exposed to methylparathion or ethylparathion (alkyl phosphates), propoxur (carbamate) or cyfluthrin (pyrethroid) was investigated. After exposure, plasma concentrations of the products or their metabolites, p-nitrophenol concentration in urine, and activities of cholinesterase and acetylcholinesterase were measured. At the same propoxur concentration, only workers with a low individual acetylcholinesterase activity reported symptoms. Workers who metabolized cyfluthrin rapidly reported fewer symptoms than workers with a lower rate of metabolism. This tendency was also evident in cases of mixed exposure (cyfluthrin and methylparathion). In the assessment of exposure to pesticides, susceptibility of the individual person has to be considered.
Descriptors (primary) chemical industry; individual susceptibility; hazard evaluation; pesticides
Descriptors (secondary) parathion; acetylcholinesterase; metabolic process; determination in urine; arprocarb; exposure evaluation; determination in blood; cyfluthrin
Document type D - Periodical articles
Country / State or ProvinceGermany
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Risk evaluation
Chemical industry
Agricultural chemicals