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Document ID (ISN)75121
CIS number 00-1060
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 1999
Convention or series no.
Author(s) Hoerauf K., Lierz M., Wiesner G., Schroegendorfer K., Lierz P., Spacek A., Brunnberg L., Nüsse M.
Title Genetic damage in operating room personnel exposed to isoflurane and nitrous oxide
Bibliographic information July 1999, Vol.56, No.7, p.433-437. Illus. 28 ref.
Abstract To evaluate possible genetic damage in lymphocytes, exposure of operating room personnel to waste anaesthetic gases was measured. Venous blood samples were drawn and lymphocytes were cultured. The operating room personnel at the hospital were exposed to an 8-hour time weighted average of 12.8ppm nitrous oxide and 5.3ppm isoflurane. The mean sister chromatid exchange frequency was significantly higher in exposed workers than controls; the proportion of micronuclei was also higher but not significant. Exposure even to trace concentrations of waste anaesthetic gases may cause dose-dependent genetic damage. Concerning the micronuclei test, no clastogenic potential could be detected after average chronic exposure to waste anaesthetic gas. However, an increased frequency of sister chromatid exchanges in human lymphocytes could be detected.
Descriptors (primary) nitrous oxide; isoflurane; genetic effects; health care personnel; operating theatres
Descriptors (secondary) lymphocytes; inhalation anaesthetics; DNA; exposure evaluation; analysis of chromosome aberrations; cell culture; determination in air; determination in blood; case-control study
Document type D - Periodical articles
Country / State or ProvinceAustria; Germany
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures
Health care services
Inorganic substances