| Document ID (ISN) | 75105 |
| CIS number |
00-1058 |
| ISSN - Serial title |
1351-0711 - Occupational and Environmental Medicine |
| Year |
1999 |
| Convention or series no. |
|
| Author(s) |
Levin J.L., O'Sullivan M.F., Corn C.J., Glenn Williams M., Dodson R.F. |
| Title |
Asbestosis and small cell lung cancer in a clutch refabricator |
| Bibliographic information |
Sep. 1999, Vol.56, No.9, p.602-605. Illus. 13 ref. |
| Abstract |
A case of asbestosis and small cell lung cancer in a clutch refabricator is described. Exposed surfaces of used clutches similar to those refabricated in the worker's workplace were rinsed, and the filtrate analysed by analytical transmission electron microscopy. Tissue samples were also analysed by this technique. Numerous chrysotile fibres of respirable dimensions and sufficient length to form ferruginous bodies (FBs) were detected from rinsed filtrates of the clutch. Bronchoalveolar lavage fluid contained many FBs, characteristic of asbestos bodies. Necropsy lung tissue showed grade 4 asbestosis and a small cell carcinoma in the right pulmonary hilum. Tissue analysis by light and analytical electron microscopy showed tissue burdens of coated and uncoated asbestos fibres greatly exceeding reported environmental concentrations (3810 FBs/g dry weight and 2,080,000 structures ≥0.5µm/g dry weight respectively). 72% of the cores were identified as chrysotile. In conclusion, clutch refabrication may lead to exposure to asbestos of sufficient magnitude to cause asbestosis and lung cancer. |
| Descriptors (primary) |
asbestos; clutches; repair work; asbestosis; lung cancer |
| Descriptors (secondary) |
case study; chrysotile; transmission electron microscopy; autopsy; asbestos bodies |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Asbestos
Pneumoconioses
Diseases of the respiratory system (except for pneumoconiosis & similar)
|
