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Document ID (ISN)75105
CIS number 00-1058
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 1999
Convention or series no.
Author(s) Levin J.L., O'Sullivan M.F., Corn C.J., Glenn Williams M., Dodson R.F.
Title Asbestosis and small cell lung cancer in a clutch refabricator
Bibliographic information Sep. 1999, Vol.56, No.9, p.602-605. Illus. 13 ref.
Abstract A case of asbestosis and small cell lung cancer in a clutch refabricator is described. Exposed surfaces of used clutches similar to those refabricated in the worker's workplace were rinsed, and the filtrate analysed by analytical transmission electron microscopy. Tissue samples were also analysed by this technique. Numerous chrysotile fibres of respirable dimensions and sufficient length to form ferruginous bodies (FBs) were detected from rinsed filtrates of the clutch. Bronchoalveolar lavage fluid contained many FBs, characteristic of asbestos bodies. Necropsy lung tissue showed grade 4 asbestosis and a small cell carcinoma in the right pulmonary hilum. Tissue analysis by light and analytical electron microscopy showed tissue burdens of coated and uncoated asbestos fibres greatly exceeding reported environmental concentrations (3810 FBs/g dry weight and 2,080,000 structures ≥0.5Ám/g dry weight respectively). 72% of the cores were identified as chrysotile. In conclusion, clutch refabrication may lead to exposure to asbestos of sufficient magnitude to cause asbestosis and lung cancer.
Descriptors (primary) asbestos; clutches; repair work; asbestosis; lung cancer
Descriptors (secondary) case study; chrysotile; transmission electron microscopy; autopsy; asbestos bodies
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Asbestos
Pneumoconioses