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Document ID (ISN)75104
CIS number 00-1049
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 1999
Convention or series no.
Author(s) Williams N.R., Jones K., Cocker J.
Title Biological monitoring to assess exposure from use of isocyanates in motor vehicle repair
Bibliographic information Sep. 1999, Vol.56, No.9, p.598-601. 18 ref.
Abstract A method for the measurement of a metabolite of hexamethylene diisocyanate (HDI) was developed and used to assess the exposure of sprayers employed in motor vehicle repair shops. Urine samples were taken from sprayers wearing personal protective equipment and spraying in booths or with local exhaust ventilation, from bystanders, and from unexposed subjects. Samples were analysed for a metabolite of HDI, hexamethylene diamine (HDA), by gas chromatography-mass spectrometry (GC-MS). HDA was detected in four sprayers and one bystander out of 22 workers. No HDA was detected in the urine of unexposed subjects. Exposure to isocyanates still occurs despite the use of personal protective equipment and the use of a booth or extracted space. Health surveillance is likely to be required to provide feedback on the adequacy of controls even if such precautions are used and to identify cases of early asthma. Biological monitoring can provide a useful additional tool to assess exposure and the adequacy of controls in this group of exposed workers.
Descriptors (primary) isocyanates; exposure evaluation; vehicle repair and servicing; paint spraying
Descriptors (secondary) hexamethylene diisocyanate; hexamethylenediamine; urinary metabolites; determination in urine; description of technique; gas chromatography; exposure tests
Document type D - Periodical articles
Country / State or ProvinceUnited Kingdom
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Exposure evaluation
Surface treatment
Isocyanates
Cyano compounds
Road transportation