|Document ID (ISN)||75083|
|ISSN - Serial title
||0002-8894 - American Industrial Hygiene Association Journal
|Convention or series no.
||Key-Schwarz R.J., Tucker S.P.
||An approach to area sampling and analysis for total isocyanates in workplace air
||Mar.-Apr. 1999, Vol.60, No.2, p.200-207. Illus. 48 ref.
||An approach to sampling and analysis for total isocyanates in workplace air was developed and evaluated. Isocyanates present in air are derivatized with a fluorescent reagent, tryptamine, in an impinger and subsequently analysed via high-performance liquid chromatography (HPLC) with fluorescence detection. Dimethyl sulfoxide (DMSO) has the advantages of being compatible with reversed-phase HPLC and not evaporating during sampling. DMSO also may dissolve aerosol particles more efficiently during sampling than relatively nonpolar solvents. Several formulations containing diisocyanate prepolymers have been tested with this method in the laboratory. This method is recommended for area sampling only due to possible hazards from contact with DMSO solutions containing isocyanate derivatives. The limits of detection are 0.1 µg/sample for 2,4-toluene diisocyanate, 0.2 µg/sample for 2,6-toluene diisocyanate, 0.3 µg/sample for methylene bisphenyl diisocyanate, and 0.2 µg/sample for 1,6-hexamethylene diisocyanate.
||isocyanates; determination in air; sampling and analysis
||high performance chromatography; dimethyl sulfoxide; description of technique; hexamethylene diisocyanate; tolylene diisocyanate; methylene diisocyanate
||D - Periodical articles
|Country / State or Province||USA|
||Toxic and dangerous substances
|Broad subject area(s)