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Document ID (ISN)75083
CIS number 00-778
ISSN - Serial title 0002-8894 - American Industrial Hygiene Association Journal
Year 1999
Convention or series no.
Author(s) Key-Schwarz R.J., Tucker S.P.
Title An approach to area sampling and analysis for total isocyanates in workplace air
Bibliographic information Mar.-Apr. 1999, Vol.60, No.2, p.200-207. Illus. 48 ref.
Abstract An approach to sampling and analysis for total isocyanates in workplace air was developed and evaluated. Isocyanates present in air are derivatized with a fluorescent reagent, tryptamine, in an impinger and subsequently analysed via high-performance liquid chromatography (HPLC) with fluorescence detection. Dimethyl sulfoxide (DMSO) has the advantages of being compatible with reversed-phase HPLC and not evaporating during sampling. DMSO also may dissolve aerosol particles more efficiently during sampling than relatively nonpolar solvents. Several formulations containing diisocyanate prepolymers have been tested with this method in the laboratory. This method is recommended for area sampling only due to possible hazards from contact with DMSO solutions containing isocyanate derivatives. The limits of detection are 0.1 µg/sample for 2,4-toluene diisocyanate, 0.2 µg/sample for 2,6-toluene diisocyanate, 0.3 µg/sample for methylene bisphenyl diisocyanate, and 0.2 µg/sample for 1,6-hexamethylene diisocyanate.
Descriptors (primary) isocyanates; determination in air; sampling and analysis
Descriptors (secondary) high performance chromatography; dimethyl sulfoxide; description of technique; hexamethylene diisocyanate; tolylene diisocyanate; methylene diisocyanate
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Isocyanates
Cyano compounds